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Volume 21, Number 2—February 2015
Research

Microbiota That Affect Risk for Shigellosis in Children in Low-Income Countries

Brianna LindsayComments to Author , Joe Oundo, M. Anowar Hossain, Martin Antonio, Boubou Tamboura, Alan W. Walker, Joseph N. Paulson, Julian Parkhill, Richard Omore, Abu S.G. Faruque, Suman Kumar Das, Usman N. Ikumapayi, Mitchell Adeyemi, Doh Sanogo, Debasish Saha, Samba Sow, Tamer H. Farag, Dilruba Nasrin, Shan Li, Sandra Panchalingam, Myron M. Levine, Karen Kotloff, Laurence S. Magder, Laura Hungerford, Halvor Sommerfelt, Mihai Pop, James P. Nataro, and O. Colin Stine
Author affiliations: University of Maryland School of Medicine, Baltimore, Maryland, USA (B. Lindsay, T.H. Farag, D. Nasrin, S. Li, S. Panchalingam, M.M. Levine, K. Kotloff, L.S. Magder, L. Hungerford, O.C. Stine); Centers for Disease Control and Prevention/Kenya Medical Research Institute Research Station, Kisumu, Kenya (J. Oundo, R. Omore); International Center for Diarrheal Disease Research, Mirzapur, Bangladesh (M.A. Hossain, A.S.G. Faruque, S.K. Das); Medical Research Council, Basse, The Gambia (M. Antonio, U.N. Ikumapayi, M. Adeyemi, D. Saha); Centre pour le Developpement des Vaccins du Mali, Bamako, Mali (B. Tamboura, D. Sanogo, S. Sow); Wellcome Trust Sanger Institute, Hinxton, UK (A.W. Walker, J. Parkhill); University of Maryland, College Park, Maryland, USA (J.N. Paulson, M. Pop); University of Queensland, Brisbane, Queensland, Australia (S.K. Das); University of Bergen, Bergen, Norway (H. Sommerfelt); Norwegian Institute of Public Health, Bergen (H. Sommerfelt); University of Virginia School of Medicine, Charlottesville, Virginia, USA (J.P. Nataro)

Main Article

Figure 2

Departure from additivity between level of ipaH gene and presence of Lactobacillus taxon TSK G32-2 on odds of moderate-to-severe diarrhea in children in low-income countries. The reference group is TSK G32-2 negative, low level of ipaH. The observed combined joint effect of a high level of the ipaH gene and TSK G32-2 was lower than the expected additive effect. Gray bars indicate effect of TSK G32-2; black bars indicate effect of high levels of ipaH; and white bar indicates observed joint effect

Figure 2. Departure from additivity between level of ipaH gene and presence of Lactobacillus taxon TSK G32-2 on odds of moderate-to-severe diarrhea in children in low-income countries. The reference group is TSK G32-2 negative, low level of ipaH. The observed combined joint effect of a high level of the ipaH gene and TSK G32-2 was lower than the expected additive effect. Gray bars indicate effect of TSK G32-2; black bars indicate effect of high levels of ipaH; and white bar indicates observed joint effect of TSK G32-2 and high levels of ipaH. Neg, negative; Pos, positive; Exp, expected; Obs, observed.

Main Article

Page created: January 20, 2015
Page updated: January 20, 2015
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