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Volume 21, Number 2—February 2015
Research

Microbiota That Affect Risk for Shigellosis in Children in Low-Income Countries

Brianna LindsayComments to Author , Joe Oundo, M. Anowar Hossain, Martin Antonio, Boubou Tamboura, Alan W. Walker, Joseph N. Paulson, Julian Parkhill, Richard Omore, Abu S.G. Faruque, Suman Kumar Das, Usman N. Ikumapayi, Mitchell Adeyemi, Doh Sanogo, Debasish Saha, Samba Sow, Tamer H. Farag, Dilruba Nasrin, Shan Li, Sandra Panchalingam, Myron M. Levine, Karen Kotloff, Laurence S. Magder, Laura Hungerford, Halvor Sommerfelt, Mihai Pop, James P. Nataro, and O. Colin Stine
Author affiliations: University of Maryland School of Medicine, Baltimore, Maryland, USA (B. Lindsay, T.H. Farag, D. Nasrin, S. Li, S. Panchalingam, M.M. Levine, K. Kotloff, L.S. Magder, L. Hungerford, O.C. Stine); Centers for Disease Control and Prevention/Kenya Medical Research Institute Research Station, Kisumu, Kenya (J. Oundo, R. Omore); International Center for Diarrheal Disease Research, Mirzapur, Bangladesh (M.A. Hossain, A.S.G. Faruque, S.K. Das); Medical Research Council, Basse, The Gambia (M. Antonio, U.N. Ikumapayi, M. Adeyemi, D. Saha); Centre pour le Developpement des Vaccins du Mali, Bamako, Mali (B. Tamboura, D. Sanogo, S. Sow); Wellcome Trust Sanger Institute, Hinxton, UK (A.W. Walker, J. Parkhill); University of Maryland, College Park, Maryland, USA (J.N. Paulson, M. Pop); University of Queensland, Brisbane, Queensland, Australia (S.K. Das); University of Bergen, Bergen, Norway (H. Sommerfelt); Norwegian Institute of Public Health, Bergen (H. Sommerfelt); University of Virginia School of Medicine, Charlottesville, Virginia, USA (J.P. Nataro)

Main Article

Table 2

Interaction between level of Shigella spp./EIEC ipaH gene and rotavirus and association with moderate-to-severe diarrhea in children in low-income countries*

Rotavirus status† Low level of ipaH gene
 High level of ipaH gene
 OR (95% CI) for ipaH gene within strata of rotavirus status
No. with MSD/ no. without MSD OR (95% CI) No. with MSD/ no. without MSD OR (95% CI)
Negative 854/1,568 1.00 (reference) 263/126 4.01 (3.18–5.05) 4.01 (3.18–5.05)
Positive
 169/40
 7.56 (5.29–10.80)
14/1
 28.85 (3.77–220)
 3.82 (0.48–30.00)
OR (95% CI) for rotavirus within strata of ipaH gene status NA 7.55 (5.29–10.80) NA 7.20 (0.93–55.57) Expected additive = 10.57

*EIEC, enteroinvasive Escherichia coli; MSD, moderate-to-severe diarrhea; OR, odds ratio; NA, not applicable.
†Model is unconditional and adjusted for age and location.

Main Article

Page created: January 20, 2015
Page updated: January 20, 2015
Page reviewed: January 20, 2015
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