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Volume 21, Number 4—April 2015
Dispatch

Pathogenicity of 2 Porcine Deltacoronavirus Strains in Gnotobiotic Pigs

Kwonil JungComments to Author , Hui Hu, Bryan Eyerly, Zhongyan Lu, Juliet Chepngeno, and Linda J. SaifComments to Author 
Author affiliations: Ohio State University, Wooster, Ohio, USA

Main Article

Table 1

Fecal shedding of virus and clinical signs after inoculation of gnotobiotic pigs with PDCoV strains OH-FD22 and OH-FD100*

Pig status, no. (age at inoculation, d) Virus strain
Oral inoculum, log10 GEs
Fecal shedding, log10 GE/mL by hpi† Clinical signs (onset hpi)
0
24
48
72
96
120
PDCoV-inoculated
1 (14) OH-FD22 8.8 <4.6 <4.6 8.1 7.3 7.4 6.7‡ Diarrhea/vomiting (21–24)§
2 (14) OH-FD22 8.8 <4.6 6.2 8.5 8.4 6.1 7.6 Diarrhea/vomiting (21–24)
3 (14) OH-FD22 8.8 <4.6 8.4 8.2 8.8‡ Diarrhea/vomiting (21–24)
4 (11) OH-FD100 11.0 <4.6 7.1 6.0 ND ND‡ Diarrhea/vomiting (22–24)
5 (11) OH-FD100 11.0 <4.6 8.2 8.5 ND‡ Diarrhea/vomiting (22–24)
Negative control
6 (16)¶ None None <4.6 <4.6 <4.6 <4.6‡ None
7 (17)¶ None None <4.6 <4.6 <4.6 <4.6‡ None

*PDCoV, porcine deltacoronavirus; GE, genome equivalent; hpi, hour postinoculation; –, no result (pig euthanized); ND, not determined.
†Detected by real-time quantitative reverse transcription PCR. The detection limit of the PCR was <4.6 log10 GE/mL for a fecal sample and <3.6 log10 GE/mL for a serum sample.
‡Pig was euthanized.
§Pig 1 vomited at days postinoculation 21–24 and then had diarrhea.
¶At euthanasia.

Main Article

Page created: March 17, 2015
Page updated: March 17, 2015
Page reviewed: March 17, 2015
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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