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Volume 21, Number 5—May 2015
Research

Protective Antibodies against Placental Malaria and Poor Outcomes during Pregnancy, Benin

Nicaise Tuikue NdamComments to Author , Lise Denoeud-Ndam, Justin Doritchamou, Firmine Viwami, Ali Salanti, Morten A. Nielsen, Nadine Fievet, Achille Massougbodji, Adrian J.F. Luty, and Philippe Deloron
Author affiliations: Institut de Recherche pour le Développement, Paris, France (N. Tuikue Ndam, L. Denoeud-Ndam, J. Doritchamou, N. Fievet, A.J.F. Luty, P. Deloron); Pôle de Recherche et d’Enseignement Supérieur Sorbonne Paris Cité, Paris (N.Tuikue Ndam, N. Fievet, A.J.F. Luty, P. Deloron),; Université d’Abomey-Calavi, Cotonou, Benin (F. Viwami, A. Massougbodji, A.J.F. Luty); University of Copenhagen, Copenhagen, Denmark (A. Salanti, M.A. Nielsen)

Main Article

Figure 4

Binding inhibitory capacity of plasma, by adverse outcomes, in pregnant women with documented Plasmodium falciparum infection during follow-up, Benin. Binding inhibition was assessed according to adverse outcomes in the subgroup of women who had ≥1 parasitemia documented between study inclusion and delivery. A) Placental infection (52 infected placentas and 214 uninfected placentas). B) Low birthweight (LBW) (36 with LBW and 254 without LBW). C) Preterm birth (29 preterm and 269 not preterm). Ho

Figure 4. Binding inhibitory capacity of plasma, by adverse outcomes, in pregnant women with documented Plasmodium falciparum infection during follow-up, Benin. Binding inhibition was assessed according to adverse outcomes in the subgroup of women who had ≥1 parasitemia documented between study inclusion and delivery. A) Placental infection (52 infected placentas and 214 uninfected placentas). B) Low birthweight (LBW) (36 with LBW and 254 without LBW). C) Preterm birth (29 preterm and 269 not preterm). Horizontal lines indicate medians, boxes indicate interquartile ranges, and error bars indicate ranges. Plasma binding inhibitory capacity was significantly higher at delivery in women without adverse outcomes (p<0.05, by Fisher exact test), and the increase between inclusion and delivery was also significant (p<0.05, by paired-Wilcoxon test). No associations were observed at inclusion. IRBCs, infected red blood cells.

Main Article

Page created: April 17, 2015
Page updated: April 17, 2015
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