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Volume 21, Number 5—May 2015
Research

Protective Antibodies against Placental Malaria and Poor Outcomes during Pregnancy, Benin

Nicaise Tuikue NdamComments to Author , Lise Denoeud-Ndam, Justin Doritchamou, Firmine Viwami, Ali Salanti, Morten A. Nielsen, Nadine Fievet, Achille Massougbodji, Adrian J.F. Luty, and Philippe Deloron
Author affiliations: Institut de Recherche pour le Développement, Paris, France (N. Tuikue Ndam, L. Denoeud-Ndam, J. Doritchamou, N. Fievet, A.J.F. Luty, P. Deloron); Pôle de Recherche et d’Enseignement Supérieur Sorbonne Paris Cité, Paris (N.Tuikue Ndam, N. Fievet, A.J.F. Luty, P. Deloron),; Université d’Abomey-Calavi, Cotonou, Benin (F. Viwami, A. Massougbodji, A.J.F. Luty); University of Copenhagen, Copenhagen, Denmark (A. Salanti, M.A. Nielsen)

Main Article

Table 1

Characteristics of 710 women and their infants in study of protective antibodies against placental malaria and poor outcomes during pregnancy, Benin*

Characteristic Value
At enrollment
Study center, no. (%)
Akodeha 279 (39)
Comé 266 (38)
Wedeme Pedah 165 (23)
Age, y, mean ± SD, n = 698 26.7 ± 6.3
Gravidity, no. (%)
Primigravidae 115 (16)
Secundigravidae 154 (22)
Multigravidae 441 (62)
Gestational age, wk, mean ± SD 16.6 ± 4.8
HIV status
Positive, no. (%) 13 (1.8)
Negative, no. (%) 697 (98.2)
Hb level, g/dL, mean ± SD, n = 704 10.6 ± 1.3
Anemia (Hb level <11 g/dL), no. (%), n = 704 439 (62)
Malaria infection, no. (%)†
116 (16)
During follow-up
No. antenatal visits, median (IQR) 5 (4–6)
Anemia during follow-up, no. (%), n = 708 619 (87)
No. malaria infections during follow-up, no. (%)†
0 384 (54)
1 183 (26)
2 89 (12)
>3 54 (8)
Treatment for malaria other than IPTp-SP, no. (%)‡
88 (12)
At delivery
Twin delivery, no. (%) 16 (2)
Birthweight, g, mean ± SD, n = 679§ 3,002 ± 486
Low birthweight infant (<2,500 g), no. (%), n = 679§ 71 (10)
Gestational age, wk, mean ± SD, n = 680§ 39.6 ± 2.0
Small for gestational age, no. (%), n = 612§ 100 (16)
Preterm birth (age <37 wk), no. (%), n = 680§ 53 (8)
Hb level, g/dL, mean ± SD, n = 649 11.0 ± 1.4
Anemia (Hb level <11 g/dL), no. (%), n = 649 289 (45)
Placental malaria detected by blood smear, no. (%), n = 60 70 (12)

*Hb, hemoglobin; IQR, interquartile range; IPTp-SP, intermittent preventive treatment in pregnancy with sulfadoxine/pyrimethamine.
†Defined by a positive blood smear regardless of symptoms.
‡82 women received quinine and 6 received other antimalarial medications.
§Excluding twins and stillbirths.

Main Article

Page created: April 17, 2015
Page updated: April 17, 2015
Page reviewed: April 17, 2015
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