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Volume 21, Number 5—May 2015

Research

Protective Antibodies against Placental Malaria and Poor Outcomes during Pregnancy, Benin

Nicaise Tuikue NdamComments to Author , Lise Denoeud-Ndam, Justin Doritchamou, Firmine Viwami, Ali Salanti, Morten A. Nielsen, Nadine Fievet, Achille Massougbodji, Adrian J.F. Luty, and Philippe Deloron
Author affiliations: Institut de Recherche pour le Développement, Paris, France (N. Tuikue Ndam, L. Denoeud-Ndam, J. Doritchamou, N. Fievet, A.J.F. Luty, P. Deloron); Pôle de Recherche et d’Enseignement Supérieur Sorbonne Paris Cité, Paris (N.Tuikue Ndam, N. Fievet, A.J.F. Luty, P. Deloron),; Université d’Abomey-Calavi, Cotonou, Benin (F. Viwami, A. Massougbodji, A.J.F. Luty); University of Copenhagen, Copenhagen, Denmark (A. Salanti, M.A. Nielsen)

Main Article

Figure 3

Binding inhibition profile of plasma from pregnant women against placental malaria, Benin. Plasma binding inhibitory capacity according to parity (n = 109 primigravidae and 573 multigravidae) (A) and to parasitemia during follow-up (B) (n = 384 women with undetected parasitemia, 115 with parasitemia detected at study inclusion, and 183 with parasitemia detected after inclusion). A) Binding inhibitory capacity was significantly higher at inclusion in multigravidae than in primigravidae and increa

Figure 3. Binding inhibition profile of plasma from pregnant women against placental malaria, Benin. Plasma binding inhibitory capacity according to parity (n = 109 primigravidae and 573 multigravidae) (A) and to parasitemia during follow-up (B) (n = 384 women with undetected parasitemia, 115 with parasitemia detected at study inclusion, and 183 with parasitemia detected after inclusion). A) Binding inhibitory capacity was significantly higher at inclusion in multigravidae than in primigravidae and increased at delivery compared with that at inclusion in both groups (all p<0.05). B) Significant increase between inclusion and delivery and a higher level at delivery in women with documented parasitemia during pregnancy (p<0.05, by Fisher exact test). Horizontal lines indicate medians, boxes indicate interquartile ranges, and error bars indicate ranges. IRBCs, infected red blood cells; AU, absorbance units.

Main Article

Page created: April 17, 2015
Page updated: April 17, 2015
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