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Volume 21, Number 5—May 2015
Research

Protective Antibodies against Placental Malaria and Poor Outcomes during Pregnancy, Benin

Nicaise Tuikue NdamComments to Author , Lise Denoeud-Ndam, Justin Doritchamou, Firmine Viwami, Ali Salanti, Morten A. Nielsen, Nadine Fievet, Achille Massougbodji, Adrian J.F. Luty, and Philippe Deloron
Author affiliations: Institut de Recherche pour le Développement, Paris, France (N. Tuikue Ndam, L. Denoeud-Ndam, J. Doritchamou, N. Fievet, A.J.F. Luty, P. Deloron); Pôle de Recherche et d’Enseignement Supérieur Sorbonne Paris Cité, Paris (N.Tuikue Ndam, N. Fievet, A.J.F. Luty, P. Deloron),; Université d’Abomey-Calavi, Cotonou, Benin (F. Viwami, A. Massougbodji, A.J.F. Luty); University of Copenhagen, Copenhagen, Denmark (A. Salanti, M.A. Nielsen)

Main Article

Table 2

Percentage of antibody responders, by parity, in study of protective antibodies against placental malaria and poor outcomes during pregnancy, Benin*

Antigen or assay Enrollment
 Delivery
All, n = 710 Primigravidae, n = 115 Multigravidae, n = 595 p value All, n = 710 Primigravidae, n = 115 Multigravidae, n = 595 p value
AMA1 77 73 78 0.265 69 70 69 0.732
VSA 67 46 71 <0.0001 58 32 63 <0.0001
DBL1–DBL2 53 41 56 0.005 46 25 50 <0.0001
DBL3 65 45 69 <0.0001 51 28 55 <0.0001
DBL4 42 40 43 0.569 46 26 50 0.002
DBL5 71 55 74 <0.0001 58 49 60 0.035
DBL6 67 70 66 0.607 81 85 80 0.434
FV2 71 51 75 <0.0001 81 70 83 0.004
IBA 59 42 62 <0.0001 66 61 67 0.168

*Antibody responders were defined as persons having an antibody level beyond the threshold. The threshold was defined for each antigen as mean reactivity + 3 SD for 30 unexposed French pregnant women. AMA1, apical membrane antigen 1; VSA, variant surface antigen; DBL, Duffy binding-like antigen; FV2, full-length ectodomain of variant surface antigen 2 chondroitin sulfate; IBA, inhibition of binding assay.

Main Article

Page created: April 17, 2015
Page updated: April 17, 2015
Page reviewed: April 17, 2015
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