Volume 21, Number 5—May 2015
Research
Protective Antibodies against Placental Malaria and Poor Outcomes during Pregnancy, Benin
Table 2
Percentage of antibody responders, by parity, in study of protective antibodies against placental malaria and poor outcomes during pregnancy, Benin*
Antigen or assay | Enrollment |
Delivery |
||||||
---|---|---|---|---|---|---|---|---|
All, n = 710 | Primigravidae, n = 115 | Multigravidae, n = 595 | p value | All, n = 710 | Primigravidae, n = 115 | Multigravidae, n = 595 | p value | |
AMA1 | 77 | 73 | 78 | 0.265 | 69 | 70 | 69 | 0.732 |
VSA | 67 | 46 | 71 | <0.0001 | 58 | 32 | 63 | <0.0001 |
DBL1–DBL2 | 53 | 41 | 56 | 0.005 | 46 | 25 | 50 | <0.0001 |
DBL3 | 65 | 45 | 69 | <0.0001 | 51 | 28 | 55 | <0.0001 |
DBL4 | 42 | 40 | 43 | 0.569 | 46 | 26 | 50 | 0.002 |
DBL5 | 71 | 55 | 74 | <0.0001 | 58 | 49 | 60 | 0.035 |
DBL6 | 67 | 70 | 66 | 0.607 | 81 | 85 | 80 | 0.434 |
FV2 | 71 | 51 | 75 | <0.0001 | 81 | 70 | 83 | 0.004 |
IBA | 59 | 42 | 62 | <0.0001 | 66 | 61 | 67 | 0.168 |
*Antibody responders were defined as persons having an antibody level beyond the threshold. The threshold was defined for each antigen as mean reactivity + 3 SD for 30 unexposed French pregnant women. AMA1, apical membrane antigen 1; VSA, variant surface antigen; DBL, Duffy binding-like antigen; FV2, full-length ectodomain of variant surface antigen 2 chondroitin sulfate; IBA, inhibition of binding assay.