Volume 21, Number 7—July 2015
Dispatch
Severe Pediatric Adenovirus 7 Disease in Singapore Linked to Recent Outbreaks across Asia
, Koh Cheng Thoon, Hui Ying Chua, Natalie Woon Hui Tan, Chia Yin Chong, Nancy Wen Sim Tee, Raymond Tzer Pin Lin, Lin Cui, Indumathi Venkatachalam, Paul Anantharajah Tambyah, Jonathan Chew, Raymond Kok Choon Fong, Helen May Lin Oh, Prabha Unny Krishnan, Vernon Jian Ming Lee, Boon Huan Tan, Sock Hoon Ng, Pei Jun Ting, Sebastian Maurer-Stroh, Vithiagaran Gunalan, and Wei Xin Khong
Table 1
Demographics and clinical features of 188 hospitalized children with adenovirus, by age group, Singapore*
|
Characteristics |
Values |
|
Median age, y (range) |
3.0 (0.2–15.7) |
|
Male sex |
120 (63.8) |
|
Positive contact history |
|
|
Yes |
79 (42.0) |
|
Unknown |
12 (6.4) |
|
Contact with confirmed adenovirus case |
|
|
Yes |
8 (10.1) |
|
Unknown |
1 (1.3) |
|
Comorbid conditions† |
35 (18.6) |
|
Symptom days before care sought, median (range) |
5 (0–21) |
|
Diagnostic method |
|
|
PCR |
51 (27.1) |
|
Immunofluorescence |
137 (72.9) |
|
Type |
|
|
4 |
40 (21.3) |
|
7 |
86 (45.7) |
|
Others (1, 2, 3, 5, 11) |
33 (17.6) |
|
Unknown |
29 (15.4) |
|
Syndrome |
|
|
Upper respiratory tract infection |
107 (56.9) |
|
Acute laryngotracheobronchitis |
1 (0.5) |
|
Bronchiolitis/bronchitis |
13 (6.9) |
|
Tonsillitis |
11 (5.9) |
|
Otitis media |
2 (1.1) |
|
Conjunctivitis |
0 |
|
Pneumonia |
35 (18.6) |
|
Gastroenteritis |
15 (8.0) |
|
Disseminated adenovirus |
1 (0.5) |
|
Hemorrhagic cystitis |
3 (1.6) |
|
Mechanical ventilation |
13 (6.9) |
|
Hospitalization days, median (range) |
4 (1–247) |
|
Died |
6 (3.2) |
*Values are no. (%) patients except as indicated.
†Comorbid conditions included primary and secondary immunodeficiencies, congenital heart disorders, chronic lung diseases, congenital malformations, inborn errors of metabolism and Down syndrome.