Volume 21, Number 7—July 2015
Dispatch
Severe Pediatric Adenovirus 7 Disease in Singapore Linked to Recent Outbreaks across Asia
, Koh Cheng Thoon, Hui Ying Chua, Natalie Woon Hui Tan, Chia Yin Chong, Nancy Wen Sim Tee, Raymond Tzer Pin Lin, Lin Cui, Indumathi Venkatachalam, Paul Anantharajah Tambyah, Jonathan Chew, Raymond Kok Choon Fong, Helen May Lin Oh, Prabha Unny Krishnan, Vernon Jian Ming Lee, Boon Huan Tan, Sock Hoon Ng, Pei Jun Ting, Sebastian Maurer-Stroh, Vithiagaran Gunalan, and Wei Xin Khong
Table 2
Number and percentages of 188 hospitalized pediatric adenovirus case-patients with noninvasive and invasive infection, by key characteristics, and risk factors associated with invasive infection, Singapore*
|
Characteristics |
Noninvasive infection, n = 134 |
Invasive infection, n = 54 |
Univariate analysis |
|
Multivariate analysis† |
||
|
Crude OR (95% CI) |
p value |
Adjusted OR (95% CI) |
p value |
||||
|
Median age, y (range) |
3.0 (0.2–15.7) |
3.1 (0.3–15.5) |
1.03 (0.95–1.12) |
0.988 |
|
1.04 (0.92–1.17) |
0.568 |
|
Male sex |
88 (65.7) |
32 (59.3) |
0.76 (0.40–1.46) |
0.331 |
|
0.53 (0.23–1.20) |
0.126 |
|
Comorbid conditions† |
14 (10.5) |
21 (38.9) |
5.45 (2.50–11.88) |
<0.001 |
|
6.78 (2.59–17.72) |
<0.001 |
|
Adenovirus type† |
|
|
|
|
|
|
|
|
4 |
37 (27.6) |
3 (5.6) |
1.00 |
|
|
1.00 |
|
|
7 |
55 (41.0) |
31 (57.4) |
6.95 (1.98–24.41) |
0.002 |
|
9.00 (2.34–34.59) |
0.001 |
|
Others (1, 2, 3, 5, 11) |
24 (17.9) |
9 (16.7) |
4.63 (1.14–18.83) |
0.033 |
|
5.33 (1.20–23.68) |
0.028 |
|
Unknown |
18 (13.4) |
11 (20.4) |
NA |
NA |
|
NA |
NA |
*Values are no. (%) patients except as indicated; OR, odds ratio; NA, not applicable.
†For multivariate analysis, variables selected in the best-fit model are shown; the model including all covariates did not alter the independent predictors.