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Volume 21, Number 7—July 2015
Dispatch

Hemagglutinin Receptor Binding of a Human Isolate of Influenza A(H10N8) Virus

Irene RamosComments to Author , Mena Mansour, Teddy J. Wohlbold, Megan E. Ermler, Ariana Hirsh, Jonathan A. Runstadler, Ana Fernandez-Sesma, and Florian KrammerComments to Author 
Author affiliations: Icahn School of Medicine at Mount Sinai, New York, New York, USA (I. Ramos, M. Mansour, T.J. Wohlbold, M.E. Ermler, A. Hirsh, A. Fernandez-Sesma, F. Krammer); Massachusetts Institute of Technology, Cambridge Massachusetts, USA (J.A. Runstadler)

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Figure 1

Receptor binding specificity of hemagglutinin of influenza A(H10N8) virus H10-JD346. A) Binding of recombinant hemagglutinins to glycans in a solid-phase binding assay. Results are means ± SEM of triplicate samples. PAA, polyacrylamide. B) Flow cytometry–based assay. H3-P99 (human), H5-Viet (avian origin isolated from a human case), and H10-mallard (avian) viruses were included in the analysis for comparison and as controls. Values at the top right of the dot plots indicate percentage of cells e

Figure 1. Receptor binding specificity of hemagglutinin of influenza A(H10N8) virus H10-JD346. A) Binding of recombinant hemagglutinins to glycans in a solid-phase binding assay. Results are means ± SEM of triplicate samples. PAA, polyacrylamide. B) Flow cytometry–based assay. H3-P99 (human), H5-Viet (avian origin isolated from a human case), and H10-mallard (avian) viruses were included in the analysis for comparison and as controls. Values at the top right of the dot plots indicate percentage of cells expressing matrix protein 2 (M2). FSC, forward-scattered light; FITC, fluorescein isothiocyanate.

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Page created: June 15, 2015
Page updated: June 15, 2015
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