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Volume 21, Number 7—July 2015
Dispatch

Hemagglutinin Receptor Binding of a Human Isolate of Influenza A(H10N8) Virus

Irene RamosComments to Author , Mena Mansour, Teddy J. Wohlbold, Megan E. Ermler, Ariana Hirsh, Jonathan A. Runstadler, Ana Fernandez-Sesma, and Florian KrammerComments to Author 
Author affiliations: Icahn School of Medicine at Mount Sinai, New York, New York, USA (I. Ramos, M. Mansour, T.J. Wohlbold, M.E. Ermler, A. Hirsh, A. Fernandez-Sesma, F. Krammer); Massachusetts Institute of Technology, Cambridge Massachusetts, USA (J.A. Runstadler)

Main Article

Table

Alignment of residues involved receptor binding of hemagglutinin of influenza A viruses*

Origin/subtype Isolate name Amino acid position (H3 numbering)
131 135 137 138 152 186 190 193 200 222 224 225 226 227 228
Human/H3N2 A/Panama/2007/1999 A T S A N S D S G W R G V S S
Human/H3N2 A/Texas/50/2012 T T S A N G D F G R R N I P S
Human/H3N2 A/Brisbane/10/2007 T T S A N V N F G R R N I P S
Human/H1N1 A/California/04/2009 D V A A I S D S T K R D Q E G
Human/H1N1 A/Texas/36/1991 V V T S L S D A A K R G Q E G
Human/H1N1 A/Brisbane/59/2007 T V A S L P D A A K R D Q E G
Avian/H1N1 A/duck/Alberta/1976 T V A A L P E S A E R G Q A G
Avian/H7N1 A/rhea/North Carolina/39482/1993 R A S A K G E K T F S G R I D
Avian/H6N1 A/mallard/Sweden/81/2002 D V K A L P E T R A N G Q R G
Avian (human isolate)/H5N1 A/Vietnam/1203/2004 A V S A V N E K T K N G Q S G
Avian (human isolate)/H7N9 A/Anhui/1/2013 R A S A K V E K K Q N G L S G
Avian/H10N7 A/shorebird/Delaware Bay/10/2004 N T R A K S E D L Q N G Q S G
Avian/H10N7 A/mallard/Interior Alaska/10BM01929/2010 N T K A K S E D L Q N G Q S G
Avian (seal isolate)/H10N7 A/harbor seal/Germany/1/2014 N T K A K S E D L Q N G Q S G
Avian (human isolate)/H10N8 A/Jiangxi-Donghu/346–1/2013 N T R A K S E D L Q N G Q S G

*Residues found in human H1 or H3 and in H10 hemagglutinin but not in other avian hemagglutinin sequences are shown in bold.

Main Article

Page created: June 15, 2015
Page updated: June 15, 2015
Page reviewed: June 15, 2015
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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