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Volume 21, Number 7—July 2015

Hemagglutinin Receptor Binding of a Human Isolate of Influenza A(H10N8) Virus

Irene RamosComments to Author , Mena Mansour, Teddy J. Wohlbold, Megan E. Ermler, Ariana Hirsh, Jonathan A. Runstadler, Ana Fernandez-Sesma, and Florian KrammerComments to Author 
Author affiliations: Icahn School of Medicine at Mount Sinai, New York, New York, USA (I. Ramos, M. Mansour, T.J. Wohlbold, M.E. Ermler, A. Hirsh, A. Fernandez-Sesma, F. Krammer); Massachusetts Institute of Technology, Cambridge Massachusetts, USA (J.A. Runstadler)

Main Article


Alignment of residues involved receptor binding of hemagglutinin of influenza A viruses*

Origin/subtype Isolate name Amino acid position (H3 numbering)
131 135 137 138 152 186 190 193 200 222 224 225 226 227 228
Human/H3N2 A/Panama/2007/1999 A T S A N S D S G W R G V S S
Human/H3N2 A/Texas/50/2012 T T S A N G D F G R R N I P S
Human/H3N2 A/Brisbane/10/2007 T T S A N V N F G R R N I P S
Human/H1N1 A/California/04/2009 D V A A I S D S T K R D Q E G
Human/H1N1 A/Texas/36/1991 V V T S L S D A A K R G Q E G
Human/H1N1 A/Brisbane/59/2007 T V A S L P D A A K R D Q E G
Avian/H1N1 A/duck/Alberta/1976 T V A A L P E S A E R G Q A G
Avian/H7N1 A/rhea/North Carolina/39482/1993 R A S A K G E K T F S G R I D
Avian/H6N1 A/mallard/Sweden/81/2002 D V K A L P E T R A N G Q R G
Avian (human isolate)/H5N1 A/Vietnam/1203/2004 A V S A V N E K T K N G Q S G
Avian (human isolate)/H7N9 A/Anhui/1/2013 R A S A K V E K K Q N G L S G
Avian/H10N7 A/shorebird/Delaware Bay/10/2004 N T R A K S E D L Q N G Q S G
Avian/H10N7 A/mallard/Interior Alaska/10BM01929/2010 N T K A K S E D L Q N G Q S G
Avian (seal isolate)/H10N7 A/harbor seal/Germany/1/2014 N T K A K S E D L Q N G Q S G
Avian (human isolate)/H10N8 A/Jiangxi-Donghu/346–1/2013 N T R A K S E D L Q N G Q S G

*Residues found in human H1 or H3 and in H10 hemagglutinin but not in other avian hemagglutinin sequences are shown in bold.

Main Article

Page created: June 15, 2015
Page updated: June 15, 2015
Page reviewed: June 15, 2015
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