Volume 22, Number 1—January 2016
Dispatch
Variations in Spike Glycoprotein Gene of MERS-CoV, South Korea, 2015
Dae-Won Kim1, You-Jin Kim1, Sung Han Park, Mi-Ran Yun, Jeong-Sun Yang, Hae Ji Kang, Young Woo Han, Han Saem Lee, Heui Man Kim, Hak Kim, A-Reum Kim, Deok Rim Heo, Su Jin Kim, Jun Ho Jeon, Deokbum Park, Joo Ae Kim, Hyang-Min Cheong, Jeong-Gu Nam, Kisoon Kim, and Sung Soon Kim
Table 2
Genetic changes in spike glycoprotein gene sequences strain-specific variants of MERS-CoV from South Korea compared with those of other MERS-CoV isolates*
| Virus isolate |
Nucleotide (amino acid) positions |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| NTD | RBD | Other regions | |||||||
| 183 | 258 | 409 | 1586 | 1588 | 1848 | 1886 | 3177 | 3267 | |
| (61) |
(86) |
(137) |
(529) |
(530) |
(616) |
(629) |
(1059) |
(1089) |
|
| JX869059_HCoV-EMC_2012 | C (G) | T (V) | A (S) | T (I) | G (V) | T (V) | G (R) | T (D) | C (S) |
| KR011266_KSA_Hu/Riyadh-KSA-2049/2015 | • | • | • | • | • | • | • | • | • |
| KR011263_KSA_Hu/Riyadh-KSA-2345/2015 | • | • | • | • | • | • | • | • | • |
| KR011264_KSA_Hu/Riyadh-KSA-2343/2015 | • | • | • | • | • | • | • | • | • |
| KR011265_KSA_Hu/Riyadh-KSA-2466/2015 | • | • | • | • | • | • | • | • | • |
| KT026453_KSA_Hu/Riyadh_KSA-2959_2015 | • | C (V) | • | • | • | • | • | • | • |
| Riyadh_KKUH_0734_20150218 | • | C (V) | • | • | • | • | • | • | • |
| Riyadh_KKUH_0756_20150223 | • | C (V) | • | • | • | • | • | • | |
| Riyadh_KKUH_0780_20150225 | • | C (V) | • | • | • | • | • | • | • |
| KT026454_KSA_Hu/Riyadh_KSA_4050_2015 | • | C (V) | • | • | • | • | • | • | • |
| Riyadh_KKUH_0944_20150302 | • | C (V) | • | • | • | • | • | • | • |
| Riyadh_KKUH_1066_20150303 | • | C (V) | • | • | • | • | • | • | • |
| Riyadh_KKUH_1080_20150303 | • | C (V) | • | • | • | • | • | • | • |
| Riyadh_KKUH_1145_20150304 | • | C (V) | • | • | • | • | • | • | • |
| Riyadh_KKUH_1470_20150308 | • | C (V) | • | • | • | • | • | • | • |
| MERS-CoV/KOR/KNIH/001_05_2015 [PAT001] | • | C (V) | • | C (T) | • | • | • | C (D) | C (S) |
| MERS-CoV/KOR/KNIH/009_05_2015 [PAT009] | • | C (V) | • | • | • | C (V) | • | C (D) | C (S) |
| ChinaGD01_2015 [PAT010]† | G (C) | C (V) | • | • | • | C (V) | • | C (D) | C (S) |
| MERS-CoV/KOR/KNIH/012_05_2015 [PAT012] | • | C (V) | • | C (T) | • | C (V) | • | C (D) | C (S) |
| MERS-CoV/KOR/KNIH/013_05_2015 [PAT013] | • | C (V) | • | C (T) | • | C (V) | • | C (D) | C (S) |
| MERS-CoV/KOR/KNIH/015_05_2015 [PAT015] | • | C (V) | • | C (T) | • | C (V) | • | C (D) | C (S) |
| MERS-CoV/KOR/KNIH/042_05_2015 [PAT042] | • | C (V) | • | C (T) | • | C (V) | A (H) | C (D) | T (S) |
| MERS-CoV/KOR/KNIH/002_05_2015 [PAT002]‡ | • | C (V) | C (R) | • | C (L) | • | • | C (D) | T (S) |
*Alphanumeric codes in brackets indicate patient (PAT) number. Dots indicate no change in sequence identity. MERS-CoV, Middle East respiratory syndrome coronavirus; NTD, N-terminal domain; RBD, receptor-binding domain. Dots indicate sequence identity.
†MERS-CoV strain ChinaGD01 (KT006149).
‡Third-passage isolate from Vero cells.
1These authors contributed equally to this article.
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