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Volume 22, Number 1—January 2016

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Schistosomiasis Screening of Travelers to Corsica, France

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EID Gautret P, Mockenhaupt FP, von Sonnenburg F, Rothe C, Libman M, Van De Winkel K, et al. Schistosomiasis Screening of Travelers to Corsica, France. Emerg Infect Dis. 2016;22(1):160-161. https://dx.doi.org/10.3201/eid2201.151606
AMA Gautret P, Mockenhaupt FP, von Sonnenburg F, et al. Schistosomiasis Screening of Travelers to Corsica, France. Emerging Infectious Diseases. 2016;22(1):160-161. doi:10.3201/eid2201.151606.
APA Gautret, P., Mockenhaupt, F. P., von Sonnenburg, F., Rothe, C., Libman, M., Van De Winkel, K....Schlagenhauf, P. (2016). Schistosomiasis Screening of Travelers to Corsica, France. Emerging Infectious Diseases, 22(1), 160-161. https://dx.doi.org/10.3201/eid2201.151606.

In response: We agree with Berry et al. (1) that the diagnostic standard for confirmation of urinary schistosomiasis is the identification of eggs by microscopic examination of urine, especially in patients living in endemic areas with high schistosome loads. However, this approach may not apply to travelers who have low parasite loads and in whom the diagnosis relies mainly on serologic testing (2,3). Given the very poor sensitivity of egg detection in non–schistosomiasis-endemic settings, most tropical and travel medicine clinics in Europe use conventional microscopy systematically combined with 2 different (commercial or in-house) serologic tests (2). The sensitivity of this approach (i.e., diagnosis of infection if combined ELISA and hemagglutination inhibition assay or an indirect fluorescent antibody test are positive) is >78% for chronic urinary schistosomiasis; specificity is 75%–98% when using various in-house and commercial kits (3). Future availability of promising ultra-sensitive tests (e.g., PCR and antigenic tests) may overcome the limitations associated with conventional microscopy and serologic testing for low-parasite load schistosomiasis.

As stated in our manuscript, we cannot exclude the possibility that our case definition generated false-positives; the potential limitations of our findings have already been discussed (4). Furthermore, we were cautious with our interpretation of the serologic test results and, therefore, claimed only 2 confirmed cases (4), 1 on the basis of egg detection and the other on positive serologic test results by using 2 different methods. We believe, on the basis of our findings (4) and in accordance with the European Centre for Disease Control experts (5), that the possibility of transmission in the Cavu River during the summer of 2014 cannot be excluded. We also want to reiterate the possibility of transmission in other rivers in Corsica, including the Solenzara, Osu, and Tarcu rivers, where Bulinus snails, which can serve as intermediate hosts for Schistosoma haematobium, were found during a malacological survey in 2014 (5).

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Philippe GautretComments to Author , Frank P. Mockenhaupt, Frank von Sonnenburg, Camilla Rothe, Michael Libman, Kristina Van De Winkel, Emmanuel Bottieau, Martin P. Grobusch, Davidson H. Hamer, Douglas H. Esposito, Philippe Parola, Patricia Schlagenhauf, and for the GeoSentinel Surveillance Network

Author affiliations: Institut Hospitalo-Universitaire Méditerranée Infection, Marseille, France (P. Gautret, P. Parola); Aix Marseille Université, Marseille (P. Gautret, P. Parola); Charité–Universitätsmedizin Berlin, Berlin, Germany (F.P. Mockenhaupt); University of Munich, Munich, Germany (F. von Sonnenburg); University Clinic Hamburg–Eppendorf, Hamburg, Germany (C. Rothe); McGill University, Montreal, Quebec, Canada (M. Libman); University Hospital, Ghent, Belgium (K. Van De Winkel); Institute of Tropical Medicine, Antwerp, Belgium (E. Bottieau); University of Amsterdam, Amsterdam, the Netherlands (M.P. Grobusch); Boston University School of Public Health, Boston, Massachusetts, USA (D.H. Hamer); Boston Medical Center, Boston (D.H. Hamer); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (D.H. Esposito); University of Zürich Centre for Travel Medicine, Zurich, Switzerland (P. Schlagenhauf)

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References

  1. Berry  A, Paris  L, Boissier  J, Caumes  E. Schistosomiasis screening of travelers to Corsica, France. [zzz.]. Emerg Infect Dis. 2016;22:159.
  2. Clerinx  J, Van Gompel  A. Schistosomiasis in travelers and migrants. Travel Med Infect Dis. 2011;9:624. DOIPubMed
  3. Kinkel  HF, Dittrich  S, Bäumer  B, Weitzel  T. Evaluation of eight serological tests for diagnosis of imported schistosomiasis. Clin Vaccine Immunol. 2012;19:94853. DOIPubMed
  4. Gautret  P, Mockenhaupt  FP, von Sonnenburg  F, Rothe  C, Libman  M, Van De Winkel  K, Local and international implications of schistosomiasis acquired in Corsica, France. Emerg Infect Dis. 2015;21:18658. DOIPubMed
  5. European Centre for Disease Prevention and Control. Rapid risk assessment: local transmission of Schistosoma haematobium in Corsica, France. Stockholm: The Centre; 2015 [cited 2015 Jul 30]. http://ecdc.europa.eu/en/publications/Publications/risk-assessment-Schistosoma%20haematobium-Corsica-update_TOR1N6.pdf

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DOI: 10.3201/eid2201.151606

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Table of Contents – Volume 22, Number 1—January 2016

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Philippe Gautret, CHU Nord, Chemin des Bourrely, 13915 Marseille, France


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