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Volume 23, Number 12—December 2017

Fatal Outbreak in Tonkean Macaques Caused by Possibly Novel Orthopoxvirus, Italy, January 20151

Giusy Cardeti2Comments to Author , Cesare Ernesto Maria Gruber2, Claudia Eleni, Fabrizio Carletti, Concetta Castilletti, Giuseppe Manna, Francesca Rosone, Emanuela Giombini, Marina Selleri, Daniele Lapa, Vincenzo Puro, Antonino Di Caro, Raniero Lorenzetti, Maria Teresa Scicluna, Goffredo Grifoni, Annapaola Rizzoli, Valentina Tagliapietra, Lorenzo De Marco, Maria Rosaria Capobianchi, and Gian Luca Autorino
Author affiliations: Istituto Zooprofilattico Sperimentale del Lazio e della Toscana M. Aleandri, Rome, Italy (G. Cardeti, C. Eleni, G. Manna, F. Rosone, R. Lorenzetti, M.T. Scicluna, G. Grifoni, G.L. Autorino); L, Spallanzani National Institute of Infectious Diseases, Rome (C.E.M. Gruber, F. Carletti, C. Castilletti, E. Giombini, M. Selleri, D. Lapa, V. Puro, A. Di Caro, M.R. Capobianchi); Fondazione Edmund Mach di San Michele all’Adige, Trento, Italy (A. Rizzoli, V. Tagliapietra); Parco Faunistico Piano dell'Abatino, Poggio San Lorenzo, Italy (L. De Marco)

Main Article

Table 5

Immunofluorescence antibody testing of vaccinated nonhuman primates after outbreak at animal sanctuary, Italy, January 2015*

Species No. animals IgM, T0/T30/T90 IgG, T0/T30/T90 No. (%) with IgG increase
Tonkean macaque (Macaca tonkeana) 4 Neg/1:20/neg Neg/1:20/1:320 4 (100)
Neg/neg/neg Neg/1:20/1:80
Neg/neg/neg Neg/neg/1:80


Cynomolgus macaque (M. fascicularis) 5 Neg/1:20/1:20 1:20/1:320/1:320 5 (100)
Neg/1:80/1:80 1:20/1:80/1:80
Neg/neg/neg Neg/1:20/1:80
Neg/1:20/1:20 Neg/1:20/1:80


Barbary macaque (M. sylvanus) 1 Neg/neg/neg 1:20/1:20/1:80 1 (100)

*Threshold dilution for antibody titers was 1:20. Neg, negative; T0, first immunization; T30, booster dose administration; T90, blood collection 60 d after T30.

Main Article

1Preliminary results from this study were presented at the Xth International Congress of the European Society for Veterinary Virology; August 31–September 3, 2015; Montpellier, France.

2These first authors were co–principal investigators who contributed equally to this article.

Page created: November 16, 2017
Page updated: November 16, 2017
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