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Volume 23, Number 2—February 2017
Research

Highly Pathogenic Influenza A(H5Nx) Viruses with Altered H5 Receptor-Binding Specificity

Hongbo Guo1, Erik de Vries1, Ryan McBride, Jojanneke Dekkers, Wenjie Peng, Kim M. Bouwman, Corwin Nycholat, M. Helene Verheije, James C. Paulson, Frank J.M. van Kuppeveld, and Cornelis A.M. de HaanComments to Author 
Author affiliations: Utrecht University, Utrecht, the Netherlands (H. Guo, E. de Vries, J. Dekkers, K.M. Bouwman, M.H. Verheije, F.J.M. van Kuppeveld, C.A.M. de Haan); The Scripps Research Institute, La Jolla, California, USA (R. McBride, W. Peng, C. Nycholat, J.C. Paulson)

Main Article

Figure 8

Structural models of influenza A virus H5 proteins complexed with 3′SLeX. A) Clade 1 H5 (H5N11 of A/Vietnam/1194/2004) complexed with 3′SLeX (PDB 3ZNM0 (29). B) H5N12.3.4 and C) H5N8 hemagglutinins were modeled into the structure shown in panel A as detailed in Materials and Methods. Key amino acids are indicated and shown in a stick representation. C (gray), O (red), and N (blue) in the side chains are colored. SIA, Gal, GlcNAc, and Fuc moieties of 3′SLeX are shown in purple, yellow, blue, and

Figure 8. Structural models of influenza A virus H5 proteins complexed with 3′SLeX. A) Clade 1 H5 (H5N11 of A/Vietnam/1194/2004) complexed with 3′SLeX (PDB 3ZNM0 (29). B) H5N12.3.4 and C) H5N8 hemagglutinins were modeled into the structure shown in panel A as detailed in Materials and Methods. Key amino acids are indicated and shown in a stick representation. C (gray), O (red), and N (blue) in the side chains are colored. SIA, Gal, GlcNAc, and Fuc moieties of 3′SLeX are shown in purple, yellow, blue, and red, respectively. Hydrogen bonds are indicated by dotted lines. H5N12.3.4, novel H5N1 virus clade 2.3.4; H5N11, H5N1 virus clade 1.

Main Article

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1These authors contributed equally to this article.

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