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Volume 23, Number 2—February 2017
Research

Highly Pathogenic Influenza A(H5Nx) Viruses with Altered H5 Receptor-Binding Specificity

Hongbo Guo1, Erik de Vries1, Ryan McBride, Jojanneke Dekkers, Wenjie Peng, Kim M. Bouwman, Corwin Nycholat, M. Helene Verheije, James C. Paulson, Frank J.M. van Kuppeveld, and Cornelis A.M. de HaanComments to Author 
Author affiliations: Utrecht University, Utrecht, the Netherlands (H. Guo, E. de Vries, J. Dekkers, K.M. Bouwman, M.H. Verheije, F.J.M. van Kuppeveld, C.A.M. de Haan); The Scripps Research Institute, La Jolla, California, USA (R. McBride, W. Peng, C. Nycholat, J.C. Paulson)

Main Article

Table 2

Detection of 3′SLeX in intestine of avian hosts of influenza A(H5Nx) virus clade 2.3.4.4 subtypes*

Order Family Common name 3′SLeX staining of intestine H5Nx virus infection†
Galliformes Phasianidae Chicken + H5N8/H5N6/H5N2
Galliformes Phasianidae Turkey ± H5N8/H5N6
Galliformes Phasianidae Quail – H5N8
Galliformes Phasianidae Pheasant + H5N2
Galliformes Phasianidae Partridge – ND
Galliformes Numididae Guinea fowl + H5N8
Anseriformes Anatidae Mallard duck – H5N8/H5N6/H5N2
Anseriformes Anatidae Teal NT H5N8/H5N6
Anseriformes Anatidae Swan NT H5N8
Anseriformes Anatidae Greylag/Canada goose – H5N8/H5N6
Columbiformes Columbidae Pigeon ++ H5N6
Falconiformes Falconidae Gyrfalcon NT H5N8
Gruiformes Gruidae Crane NT H5N8
Strigiformes Strigidae Snowy owl NT H5N2
Acipitriformes Accipitridae Cooper’s hawk/bald eagle NT H5N2/H5N8

*ND, not detected; NT, not tested; SLe, sialyl Lewis; –, no visible staining; ±, few cells weakly stained; +, intense staining of cells; ++, intense staining of many cells.
†Subtypes identified in different bird species on the basis of data from GenBank and GISAID (http://platform.gisaid.org).

Main Article

1These authors contributed equally to this article.

Page created: January 17, 2017
Page updated: January 17, 2017
Page reviewed: January 17, 2017
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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