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Volume 23, Number 3—March 2017
Research

Whole-Genome Analysis of Bartonella ancashensis, a Novel Pathogen Causing Verruga Peruana, Rural Ancash Region, Peru

Kristin E. Mullins12Comments to Author , Jun Hang2, Robert J. Clifford2, Fatma Onmus-Leone, Yu Yang, Ju Jiang, Mariana Leguia, Matthew R. Kasper, Ciro Maguina, Emil P. Lesho, Richard G. Jarman, Allen L. Richards, and David Blazes
Author affiliations: Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA (K.E. Mullins, J. Jiang, A. Richards, D. Blazes); US Naval Medical Research Center, Silver Spring, Maryland, USA (K.E. Mullins, A. Richards); Walter Reed Army Institute of Research, Silver Spring (J. Hang, R.J. Clifford, F. Onmus-Leone, Y. Yang, E.P. Lesho, R.G. Jarman); US Naval Medical Research Unit No. 6, Lima, Peru (M. Leguia, M.R. Kasper); Universidad Peruana Cayetano Heredia, Lima (C. Maguina)

Main Article

Figure 3

Proteomic analysis of Bartonella ancashensis isolated from patients with verruga peruana, rural Ancash region, Peru, and 10 related Bartonella species. A) Density plot showing similarity between B. ancashensis protein-coding genes and genes from 10 of the more closely related Bartonella species. Similarity scores are based on the BLAST score ratio method (BSR) (25). A score of 1.0 indicates identity between 2 proteins, and a score <0.3 indicates that the 2 proteins do not show meaningful simi

Figure 3. Proteomic analysis of Bartonella ancashensis isolated from patients with verruga peruana, rural Ancash region, Peru, and 10 related Bartonella species. A) Density plot showing similarity between B. ancashensis protein-coding genes and genes from 10 of the more closely related Bartonella species. Similarity scores are based on the BLAST score ratio method (BSR) (25). A score of 1.0 indicates identity between 2 proteins, and a score <0.3 indicates that the 2 proteins do not show meaningful similarity. The Bartonella species whose protein similarity score distribution has a peak closest to 1 (B. bacilliformis) has the highest overall protein similarity to B. ancashensis. Horizontal gray line indicates density = 0. B) Presence of homologous protein-coding genes in B. ancashensis and 15 Bartonella species. Proteins from 2 species with a BSR score >0.3 were considered to be homologs and present in B. ancashensis and >1 Bartonella species.

Main Article

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Main Article

1Current affiliation: University of Maryland, Baltimore, Maryland, USA.

2These authors contributed equally to this article.

Page created: February 17, 2017
Page updated: February 17, 2017
Page reviewed: February 17, 2017
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