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Volume 23, Number 5—May 2017

CME ACTIVITY - Research

Increased Neurotropic Threat from Burkholderia pseudomallei Strains with a B. mallei–like Variation in the bimA Motility Gene, Australia

Jodie L. MorrisComments to Author , Anne Fane, Derek S. Sarovich, Erin P. Price, Catherine M. Rush, Brenda L. Govan, Elizabeth Parker, Mark Mayo, Bart J. Currie, and Natkunam Ketheesan
Author affiliations: James Cook University, Townsville, Queensland, Australia (J.L. Morris, A. Fane, C.M. Rush, B.L. Govan, E. Parker, N. Ketheesan); Menzies School of Health Research, Darwin, Northern Territory, Australia (D.S. Sarovich, E.P. Price, M. Mayo, B.J. Currie); Royal Darwin Hospital, Darwin (B.J. Currie)

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Figure 2

Brain bacterial loads in mice that had signs of neurologic involvement and succumbed to infection with MSHR543 (bimBm) and MSHR305 (bimBp) Burkholderia pseudomallei isolates. Bacterial loads in brains of C57BL/6 mice (MSHR543, n = 4; MSHR305, n = 5) that had become moribund and required euthanasia within the 21-day experimental period after intranasal infection with MSHR543 (1.4 × 104 CFU; white bars) and MSHR305 (1.1 × 104 CFU; black bars). N indicates mice that displayed symptoms of neurologic

Figure 2. Brain bacterial loads in mice that had signs of neurologic involvement and succumbed to infection with MSHR543 (bimBm) and MSHR305 (bimBp) Burkholderia pseudomallei isolates. Bacterial loads in brains of C57BL/6 mice (MSHR543, n = 4; MSHR305, n = 5) that had become moribund and required euthanasia within the 21-day experimental period after intranasal infection with MSHR543 (1.4 × 104 CFU; white bars) and MSHR305 (1.1 × 104 CFU; black bars). N indicates mice that displayed symptoms of neurologic involvement. Data are expressed as log10 CFU. Mice exposed to MSHR543 (bimBm) had signs of neurologic involvement and became moribund within 7 days of exposure.

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