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Volume 23, Number 5—May 2017

CME ACTIVITY - Research

Increased Neurotropic Threat from Burkholderia pseudomallei Strains with a B. mallei–like Variation in the bimA Motility Gene, Australia

Jodie L. MorrisComments to Author , Anne Fane, Derek S. Sarovich, Erin P. Price, Catherine M. Rush, Brenda L. Govan, Elizabeth Parker, Mark Mayo, Bart J. Currie, and Natkunam Ketheesan
Author affiliations: James Cook University, Townsville, Queensland, Australia (J.L. Morris, A. Fane, C.M. Rush, B.L. Govan, E. Parker, N. Ketheesan); Menzies School of Health Research, Darwin, Northern Territory, Australia (D.S. Sarovich, E.P. Price, M. Mayo, B.J. Currie); Royal Darwin Hospital, Darwin (B.J. Currie)

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Figure 3

Central nervous system pathology in mice that had signs of neurologic involvement and succumbed to infection with bimBm and bimBp Burkholderia pseudomallei isolates. Evidence of central nervous system pathology was demonstrated in these mice. Inflammatory infiltrates were prominent in trigeminal nerve branches and ganglion (original magnification ×400) (A) and in the olfactory bulb (original magnification ×200) (B). Cranial meningitis (C) and spinal (D) meningitis were observed, often with invol

Figure 3. Central nervous system pathology in mice that had signs of neurologic involvement and succumbed to infection with bimBm and bimBp Burkholderia pseudomallei isolates. Evidence of central nervous system pathology was demonstrated in these mice. Inflammatory infiltrates were prominent in trigeminal nerve branches and ganglion (original magnification ×400) (A) and in the olfactory bulb (original magnification ×200) (B). Cranial meningitis (C) and spinal (D) meningitis were observed, often with involvement of underlying parenchyma (original magnification ×400). Microabscesses were frequently observed in cerebral cortex (original magnification ×100) (E), brainstem (not shown) and cerebellum (not shown) of mice that had neurologic symptoms and succumbed to infection.

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