Figure 4. Comparison of early bacterial dissemination and persistence after intranasal infection of C57BL/6 mice with MSHR543 (bimBm) and MSHR305 (bimBp) Burkholderia pseudomallei isolates. A, B) Bacterial load at day 1 (A) and day 3 (B) postinfection in nasal-associated lymphoid tissue, brain, cervical lymph nodes, lung, spleen, liver, and blood after intranasal infection of C57BL/6 mice (n = 5/time point) with MSHR543 (1.4 × 104 CFU; white bars) and MSHR305 (1.1 × 104 CFU; black bars). C) Bacterial organ loads in mice that survived the 21-day experimental period (MSHR543, n = 6; MSHR305, n = 5). Data are expressed as mean log10 CFU + SD (upper bars only). cLN, cervical lymph nodes; NALT, nasal-associated lymphoid tissue; ND, not detected. *p<0.05; **p<0.01.