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Volume 23, Number 5—May 2017

CME ACTIVITY - Research

Increased Neurotropic Threat from Burkholderia pseudomallei Strains with a B. mallei–like Variation in the bimA Motility Gene, Australia

Jodie L. MorrisComments to Author , Anne Fane, Derek S. Sarovich, Erin P. Price, Catherine M. Rush, Brenda L. Govan, Elizabeth Parker, Mark Mayo, Bart J. Currie, and Natkunam Ketheesan
Author affiliations: James Cook University, Townsville, Queensland, Australia (J.L. Morris, A. Fane, C.M. Rush, B.L. Govan, E. Parker, N. Ketheesan); Menzies School of Health Research, Darwin, Northern Territory, Australia (D.S. Sarovich, E.P. Price, M. Mayo, B.J. Currie); Royal Darwin Hospital, Darwin (B.J. Currie)

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Figure 4

Comparison of early bacterial dissemination and persistence after intranasal infection of C57BL/6 mice with MSHR543 (bimBm) and MSHR305 (bimBp) Burkholderia pseudomallei isolates. A, B) Bacterial load at day 1 (A) and day 3 (B) postinfection in nasal-associated lymphoid tissue, brain, cervical lymph nodes, lung, spleen, liver, and blood after intranasal infection of C57BL/6 mice (n = 5/time point) with MSHR543 (1.4 × 104 CFU; white bars) and MSHR305 (1.1 × 104 CFU; black bars). C) Bacterial orga

Figure 4. Comparison of early bacterial dissemination and persistence after intranasal infection of C57BL/6 mice with MSHR543 (bimBm) and MSHR305 (bimBp) Burkholderia pseudomallei isolates. A, B) Bacterial load at day 1 (A) and day 3 (B) postinfection in nasal-associated lymphoid tissue, brain, cervical lymph nodes, lung, spleen, liver, and blood after intranasal infection of C57BL/6 mice (n = 5/time point) with MSHR543 (1.4 × 104 CFU; white bars) and MSHR305 (1.1 × 104 CFU; black bars). C) Bacterial organ loads in mice that survived the 21-day experimental period (MSHR543, n = 6; MSHR305, n = 5). Data are expressed as mean log10 CFU + SD (upper bars only). cLN, cervical lymph nodes; NALT, nasal-associated lymphoid tissue; ND, not detected. *p<0.05; **p<0.01.

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