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Volume 23, Number 6—June 2017

Research

Distribution and Quantitative Estimates of Variant Creutzfeldt-Jakob Disease Prions in Tissues of Clinical and Asymptomatic Patients

Jean Y. Douet, Caroline Lacroux, Naima Aron, Mark W. Head, Séverine Lugan, Cécile Tillier, Alvina Huor, Hervé Cassard, Mark Arnold, Vincent Beringue, James W. Ironside, and Olivier AndréolettiComments to Author 
Author affiliations: Institut National de la Recherche Agronomique, Toulouse, France (J.Y. Douet, C. Lacroux, N. Aron, S. Lugan, C. Tillier, A. Huor, H. Cassard, O. Andréoletti); University of Edinburgh, Edinburgh, Scotland, UK (M.W. Head, J.W. Ironside); Animal and Plant Health Agency, Loughborough, UK (M. Arnold); Institut National de la Recherche Agronomique, Jouy-en-Josas, France (V. Beringue)

Main Article

Table 3

Characteristics of 5 patients with vCJD and 2 controls in study of distribution and quantitative estimates of variant prions in tissues*

Patient identification no. Diagnosis Sex Year of death Age, y, at death Disease duration, mo PRNP gene codon 129 PRNP gene mutations
vCJD-1 vCJD M 1999 33 18 MM None detected
vCJD-2 vCJD F 2000 17 18 MM None detected
vCJD-4 vCJD M 2000 26 10 MM None detected
vCJD-3 vCJD M 2001 26 10 MM None detected
vCJD-A Asymptomatic vCJD F 2004 82 NA MV None detected
NC-1 No CJD (tumor, infarction, ischemia) F 2005 85 NA MM No consent for sequencing
NC-2 No CJD (Alzheimer’s disease, infarction, ischemia) F 2010 80 NA MM None detected

*NA, not applicable; vCJD, variant Creutzfeldt-Jakob disease.

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