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Volume 23, Number 6—June 2017

Research

Distribution and Quantitative Estimates of Variant Creutzfeldt-Jakob Disease Prions in Tissues of Clinical and Asymptomatic Patients

Jean Y. Douet, Caroline Lacroux, Naima Aron, Mark W. Head, Séverine Lugan, Cécile Tillier, Alvina Huor, Hervé Cassard, Mark Arnold, Vincent Beringue, James W. Ironside, and Olivier AndréolettiComments to Author 
Author affiliations: Institut National de la Recherche Agronomique, Toulouse, France (J.Y. Douet, C. Lacroux, N. Aron, S. Lugan, C. Tillier, A. Huor, H. Cassard, O. Andréoletti); University of Edinburgh, Edinburgh, Scotland, UK (M.W. Head, J.W. Ironside); Animal and Plant Health Agency, Loughborough, UK (M. Arnold); Institut National de la Recherche Agronomique, Jouy-en-Josas, France (V. Beringue)

Main Article

Figure 5

Dose–response relationship for A) incubation period and B) probability of infection of bovine PrP–expressing mice. Data were derived from an endpoint titration of 10% (wt/vol) frontal cortex homogenate from a patient with variant Creutzfeldt-Jakob disease. This homogenate was inoculated into tgBov mice (20 μL by intracerebral [ic] route; Table 1). This procedure was used to establish a model that estimates infectious titer in a homogenate on the basis of incubation period and the probability of

Figure 5. Dose–response relationship for A) incubation period and B) probability of infection of bovine PrP–expressing mice. Data were derived from an endpoint titration of 10% (wt/vol) frontal cortex homogenate from a patient with variant Creutzfeldt-Jakob disease. This homogenate was inoculated into tgBov mice (20 μL by intracerebral [ic] route; Table 1). This procedure was used to establish a model that estimates infectious titer in a homogenate on the basis of incubation period and the probability of infection in inoculated mice. Model plots are indicated by solid lines. +, observed value. LD50, 50% lethal dose.

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