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Volume 24, Number 1—January 2018
Research

Emergence of Vaccine-Derived Polioviruses during Ebola Virus Disease Outbreak, Guinea, 2014–2015

Maria Dolores Fernandez-GarciaComments to Author , Manasi Majumdar, Ousmane Kebe, Aichatou D. Fall, Moussa Kone, Mouctar Kande, Moustapha Dabo, Mohamed Salif Sylla, Djenou Sompare, Wayne Howard, Ousmane Faye, Javier Martin1, and Kader Ndiaye1
Author affiliations: Institut Pasteur, Dakar, Senegal (M.D. Fernandez-Garcia, O. Kebe, A.D. Fall, O. Faye, K. Ndiaye); National Institute for Biological Standards and Control, Potters Bar, UK (M. Majumdar, J. Martin); World Health Organization, Conakry, Guinea (M. Kone, M. Kande); Guinean Ministry of Health, Conakry (M. Dabo, M.S. Sylla, D. Sompare); National Institute for Communicable Diseases, Johannesburg, South Africa (W. Howard)

Main Article

Table 1

Clinical and virologic features for case-patients and contacts from whom laboratory-confirmed type 2 cVDPVs were isolated from fecal samples, Guinea, 2014–2015*

Name† Subpref‡ Paralysis onset date Date of first sample Paralysis within 3 d Asymm. paralysis No. OPV doses Date of last OPV No. VP1 nt changes vs. Sabin-2 % Match Sabin-2 GenBank accesion no.
Case-patient no., age, y/sex
14-120, 4/M Kintinian 2014 Aug 30 2014 Sep 6 Yes No 1 2013 Oct 25 12 98.67 MF322697
15-078, 3/F Kankan 2015 Sep 7 2015 Sep 10 No No 2 2015 Jun 5 22 97.56 MF322698
15-114, 3/M Kintinian 2015 Sep 30 2015 Oct 9 Yes No 1 2012 May 12 20 97.78 MF322699
15-115, 1/M Doko 2015 Oct 2 2015 Oct 18 No No 1 2015 Sep 18 24 97.34 MF322700
15-136, 4/M Kintinian 2015 Oct 10 2015 Nov 10 Yes No 2 2015 Oct 1 27 97 MF322701
15-170, 1/M
 Doko
 2015 Dec 14
 2015 Dec 18
 No
 Yes
 0
 NR
 23
 97.45
 MF322702
Contact no., age, y/sex
15-114-C6, 1/F Kintinian NA 2015 Dec 25 NA NA 3 2015 Dec 6 22 97.56 MF322703
15-115-C4, 1/F Doko NA 2015 Oct 22 NA NA 2 2015 Sep 28 22 97.56 MF322704
15-115-C5, 3/F Doko NA 2015 Oct 22 NA NA 2 2015 Oct 29 22 97.56 MF322705
15-115-C8, 4/M Doko NA 2015 O t 23 NA NA 2 2015 Sep 29 20 97.78 MF322706
15-115-C10, 0.58/F Doko NA 2015 Dec 23 NA NA 1 2015 Dec 6 23 97.45 MF322707
15-136-C1, 1/F Kintinian NA 2015 Dec 11 NA NA 1 2015 Dec 9 24 97.34 MF322708
15-136-C2, 0.5/F Kintinian NA 2015 Dec 10 NA NA 1 2015 Dec 9 25 97.23 MF322709

*AFP, acute flaccid paralysis; Asymm., asymmetrical; cVDPV, circulating vaccine-derived poliovirus; NA, not applicable; NR, vaccine not received; OPV, oral polio vaccine; subpref, subprefecture; VP, capsid viral protein.
†All case-patients had AFP and fever at onset of paralysis. No contact had AFP.
‡All case-patients and contacts were from Siguiri Prefecture, except 15-078 (Doko Prefecture).

Main Article

1These authors contributed equally to this article.

Page created: December 19, 2017
Page updated: December 19, 2017
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