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Volume 24, Number 2—February 2018

Research

Multiplex PCR−Based Next-Generation Sequencing and Global Diversity of Seoul Virus in Humans and Rats

Won-Keun Kim1, Jin Sun No1, Seung-Ho Lee, Dong Hyun Song, Daesang Lee, Jeong-Ah Kim, Se Hun Gu, Sunhye Park, Seong Tae Jeong, Heung-Chul Kim, Terry A. Klein, Michael R. Wiley, Gustavo Palacios, and Jin-Won SongComments to Author 
Author affiliations: Korea University, Seoul, South Korea (W.-K. Kim, J.S. No, S.-H. Lee, J.-A. Kim, J.-W. Song); Agency for Defense Development, Daejeon, South Korea (D.H. Song, D. Lee, S.H. Gu, S. Park, S.T. Jeong); 65th Medical Brigade/Medical Department Activity−Korea, Seoul (H.-C. Kim, T.A. Klein); US Army Medical Research Institute of Infectious Disease, Fort Detrick, Maryland, USA (M.R. Wiley, G. Palacios)

Main Article

Figure 4

Phylogenetic analysis of SEOV large RNA segments, South Korea, 2000–2016, and reference strains. A phylogenetic tree was generated by using the maximum-likelihood method with the TN93 + gamma + invariant model of evolution and alignment of large segment sequences (nt 1–6510) of SEOV strains. Colored groups indicate the areas where SEOV strains were identified: group A, southeastern China and North Korea; group B, Europe (France); group C, South Korea and the United States; group E, United Kingdo

Figure 4. Phylogenetic analysis of SEOV large RNA segments, South Korea, 2000–2016, and reference strains. A phylogenetic tree was generated by using the maximum-likelihood method with the TN93 + gamma + invariant model of evolution and alignment of large segment sequences (nt 1–6510) of SEOV strains. Colored groups indicate the areas where SEOV strains were identified: group A, southeastern China and North Korea; group B, Europe (France); group C, South Korea and the United States; group E, United Kingdom and the United States. Bold red indicates SEOV strains sequenced in this study. Topologies were evaluated by bootstrap analyses of 1,000 iterations. Numbers along branches are bootstrap values. GenBank accession number are provided. Scale bar indicates nucleotide substitutions per site. SEOV, Seoul virus.

Main Article

1These authors contributed equally to this article.

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