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Volume 24, Number 2—February 2018
Research

Multiplex PCR−Based Next-Generation Sequencing and Global Diversity of Seoul Virus in Humans and Rats

Won-Keun Kim1, Jin Sun No1, Seung-Ho Lee, Dong Hyun Song, Daesang Lee, Jeong-Ah Kim, Se Hun Gu, Sunhye Park, Seong Tae Jeong, Heung-Chul Kim, Terry A. Klein, Michael R. Wiley, Gustavo Palacios, and Jin-Won SongComments to Author 
Author affiliations: Korea University, Seoul, South Korea (W.-K. Kim, J.S. No, S.-H. Lee, J.-A. Kim, J.-W. Song); Agency for Defense Development, Daejeon, South Korea (D.H. Song, D. Lee, S.H. Gu, S. Park, S.T. Jeong); 65th Medical Brigade/Medical Department Activity−Korea, Seoul (H.-C. Kim, T.A. Klein); US Army Medical Research Institute of Infectious Disease, Fort Detrick, Maryland, USA (M.R. Wiley, G. Palacios)

Main Article

Figure 3

Phylogenetic analysis of SEOV medium RNA segments, South Korea, 2000–2016, and reference strains. A phylogenetic tree was generated by using the maximum-likelihood method with the general time reversible + gamma + invariant model of evolution and alignment of medium segment sequences (nt 47–3430) of SEOV strains. Colored groups indicate the areas where SEOV strains were identified: group A, northeastern and southeastern China and North Korea; group B, Europe (France and Belgium) and Southeast As

Figure 3. Phylogenetic analysis of SEOV medium RNA segments, South Korea, 2000–2016, and reference strains. A phylogenetic tree was generated by using the maximum-likelihood method with the general time reversible + gamma + invariant model of evolution and alignment of medium segment sequences (nt 47–3430) of SEOV strains. Colored groups indicate the areas where SEOV strains were identified: group A, northeastern and southeastern China and North Korea; group B, Europe (France and Belgium) and Southeast Asia (Vietnam and Singapore); group C, South Korea, Japan, and the United States; group D, southeastern China; group E, United Kingdom and the United States; group F, mountainous areas in southeastern China. Bold red indicates SEOV strains sequenced in this study. Topologies were evaluated by bootstrap analyses of 1,000 iterations. Numbers along branches are bootstrap values. GenBank accession numbers are provided. Scale bar indicates nucleotide substitutions per site. SEOV, Seoul virus.

Main Article

1These authors contributed equally to this article.

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