Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 24, Number 3—March 2018
CME ACTIVITY - Synopsis

Epidemiology of Recurrent Hand, Foot and Mouth Disease, China, 2008–2015

Jiao Huang1, Qiaohong Liao1, Mong How Ooi, Benjamin J. Cowling, Zhaorui Chang, Peng Wu, Fengfeng Liu, Yu Li, Li Luo, Shuanbao Yu, Hongjie Yu2Comments to Author , and Sheng Wei2Comments to Author 
Author affiliations: Huazhong University of Science and Technology, Wuhan, China (J. Huang, S. Wei); Chinese Center for Disease Control and Prevention, Beijing, China (J. Huang, Q. Liao, Z. Chang, F. Liu, Y. Li, L. Luo, S. Yu, H. Yu); Sarawak General Hospital, Kuching, Malaysia (M.H. Ooi); Universiti Malaysia Sarawak, Kota Samarahan, Malaysia (M.H. Ooi); The University of Hong Kong, Hong Kong, China (B.J. Cowling, P. Wu, Y. Li); Fudan University, Shanghai, China (H. Yu)

Main Article

Table 2

Risk factors associated with severe illness in cases of recurrent laboratory-confirmed HFMD, China, 2008–2015*

Risk factor Mild, N = 3,187, no. (%) Severe, N = 172, no. (%) Adjusted OR (95% CI)
Age at HFMD onset, mo
  >23 2,054 (96.9) 66 (3.1) Reference
  12–23 836 (91.5) 78 (8.5) 2.4 (1.7–3.6)
  <12
 297 (91.4)
 28 (8.6)
 2.6 (1.6–4.4)
Sex
  F 1,010 (95.5) 48 (4.5) Reference
  M
 2,177 (94.6)
 124 (5.4)
 0.9 (0.6–1.2)
Enterovirus serotype
  CV-A16 857 (98.5) 13 (1.5) Reference
  Other EVs 1,452 (96.0) 61 (4.0) 2.7 (1.5–5.0)
  EV-A71
 878 (90.0)
 98 (10.0)
 7.2 (4.0–13.0)
Residence
  Rural 1,342 (92.8) 104 (7.2) Reference
  Urban
 1,845 (96.4)
 68 (3.6)
 1.8 (1.3–2.5)
Order episode occurred
  First 1,523 (93.9) 99 (6.1) Reference
  Second or after
 1,664 (95.8)
 73 (4.2)
 0.8 (0.5–1.2)
Onset-to-diagnosis interval
  <1 d 1,443 (96.3) 55 (3.7) Reference
  2–3 d 896 (94.0) 57 (6.0) 1.6 (1.1–2.4)
  >4 d 848 (93.4) 60 (6.6) 1.8 (1.2–2.7)
Interval between successive episodes 0.97 (0.95–1.01)

*CV-A16, coxsackievirus A16; EV-A71, enterovirus A71; HFMD, hand, foot and mouth disease; OR, odds ratio; other EVs, other non–EV-A71 and non–CV-A16 enteroviruses.

Main Article

1These first authors contributed equally to this article.

2These senior authors contributed equally to this article.

Page created: February 12, 2018
Page updated: February 12, 2018
Page reviewed: February 12, 2018
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external