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Volume 24, Number 8—August 2018

Susceptibility of Human Prion Protein to Conversion by Chronic Wasting Disease Prions

Marcelo A. BarriaComments to Author , Adriana Libori, Gordon Mitchell, and Mark W. Head
Author affiliations: National CJD Research and Surveillance Unit, University of Edinburgh, Edinburgh, Scotland, UK (M.A. Barria, A. Libori, M.W. Head); National and OIE Reference Laboratory for Scrapie and CWD, Canadian Food Inspection Agency, Ottawa, Ontario, Canada (G. Mitchell)

Main Article


Description of cervid CWD specimens used to evaluate the susceptibility of human prion protein to conversion by in vitro conversion analysis*

Species Common name
Specimen ID Disease in captive animals or experimental transmission Prnp genotype, known relevant polymorphisms
North America Europe
Cervus canadensis
North American or Rocky Mountain elk or wapiti
Closely related to red deer (Cervus elaphus)
Elk 0† Captive 132 MM
Elk 1 Captive 132 MM
Elk 2 Captive 132 MM
Elk 3 Captive 132 MM
Elk 4 Captive 132 MM
Elk 5 Captive 132 ML
Elk 6
132 ML
Odocoileus virginianus
White-tailed deer
Related to roe deer (Capreolus capreolus)
WTD 1 Experimental 96 GG
96 GG
Rangifer tarandus subspecies Caribou (free-ranging) or reindeer (captive) Reindeer (free-ranging and captive) Reindeer 1 Experimental (transmission of WTD [CWD 96GG])‡ §
Reindeer 2 Experimental [transmission of WTD (CWD 96GG)]¶ §

*CWD, chronic wasting disease; WTD, white-tailed deer.
†Previously reported in Barria et al. (15).
‡Case 12 previously reported in Mitchell et al. (19).
§Reportedly identical to the case of CWD in a wild reindeer in Norway (Benestad et al. [2]).
¶Case 47 previously reported in Mitchell et al. (19).

Main Article

Page created: July 17, 2018
Page updated: July 17, 2018
Page reviewed: July 17, 2018
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