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Volume 25, Number 2—February 2019

Trends of Human Plague, Madagascar, 1998–2016

Voahangy Andrianaivoarimanana1, Patrice Piola12, David M. Wagner, Fanjasoa Rakotomanana, Viviane Maheriniaina, Samuel Andrianalimanana, Suzanne Chanteau3, Lila Rahalison4, Maherisoa Ratsitorahina, and Minoarisoa RajerisonComments to Author 
Author affiliations: Institut Pasteur, Antananarivo, Madagascar (V. Andrianaivoarimanana, P. Piola, F. Rakotomanana, S. Chanteau, L. Rahalison, M. Rajerison); Northern Arizona University, Flagstaff, Arizona, USA (D.M. Wagner); Ministry of Public Health, Antananarivo (V. Maheriniaina, S. Andrianalimanana, M. Ratsitorahina)

Main Article

Table 1

Sensitivity and specificity of microscopy and F1RDT for the diagnosis of human plague cases, Madagascar*

Clinical form Microscopy, 1998–2001
F1RDT, 2002–2008
Sensitivity Specificity Sensitivity Specificity
Bubonic 34% (31%–38%) 96% (95%–97%) 100% (99%–100%) 60% (58%–62%)
53% (34%–71%)
94% (84%–98%)

100% (90%–100%)
45% (37%–52%)
Total 35% (32%–39%) 96% (95%–97%) 100% (99%–100%) 59% (57%–61%)

*Values in parentheses are ranges. Bacteriological culture was used as a reference test. F1RDT, Yersinia pestis antigen fraction 1 rapid diagnostic test.

Main Article

1These authors contributed equally to this article.

2Current affiliation: Institut Pasteur, Phnom Penh, Cambodia.


4Current affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Page created: January 18, 2019
Page updated: January 18, 2019
Page reviewed: January 18, 2019
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