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Volume 25, Number 4—April 2019
Research

Differences in Neuropathogenesis of Encephalitic California Serogroup Viruses

Alyssa B. Evans, Clayton W. Winkler, and Karin E. PetersonComments to Author 
Author affiliations: National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA

Main Article

Table 2

Cell death and replication kinetics of 5 encephalitic California serogroup viruses in human neural stem cells*

Virus
 MOI 0.01
MOI 0.001
Difference in cell death†
Virus replication
 Difference in cell death†
Virus replication
Range, hpi
 p value range
 Replication rate p value‡
 Peak titer, PFU/mL
 hpi§
 Range, hpi
 p value range
 Replication rate p value‡
 Peak titer, PFU/mL
 hpi§
LACV Ref Ref Ref 3.63 × 108 48 Ref Ref Ref 1.34 × 109 48
SSHV 34–49 0.042–0.013 0.018 4.48 × 107 48 49–94 0.044–0.001 0.091 3.82 × 108 48
TAHV 43–61 0.043–0.025 0.050 1.16 × 108 48 64–70 0.047–0.044 0.042 1.08 × 108 48
JCV 34–73 0.027–0.003 0.012 6.42 × 106 48 58–76 0.037–0.015 0.033 2.21 × 107 96
INKV 34–79 0.026–0.0001 0.075 1.43 × 108 48 46–96 0.045–0.0001 0.035 1.30 × 108 96

*All statistical comparisons were made with LACV used as the reference. hpi, hour postinoculation; INKV, Inkoo virus; JCV, Jamestown Canyon virus; LACV, La Crosse virus; MOI, multiplicity of infection; NS, not significant; Ref, referent; SSHV, snowshoe hare virus; TAHV, Tahyna virus.
†Cell death for >3 independent experiments analyzed by 2-way analysis of variance.
‡Replication rates from 3 independent experiments were analyzed via linear regression analysis of slopes during the log phase of viral growth (6–48 hpi). Significant p values (<0.05) are in boldface.
§Time point at which the sampled peak titer was observed.

Main Article

Page created: March 18, 2019
Page updated: March 18, 2019
Page reviewed: March 18, 2019
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