Volume 25, Number 5—May 2019
Research
Lassa Virus Targeting of Anterior Uvea and Endothelium of Cornea and Conjunctiva in Eye of Guinea Pig Model
Joy M. Gary, Stephen R. Welch, Jana M. Ritter, JoAnn Coleman-McCray, Thanhthao Huynh, Markus H. Kainulainen, Brigid C. Bollweg, Vaunita Parihar, Stuart T. Nichol, Sherif R. Zaki, Christina F. Spiropoulou, and Jessica R. Spengler
Figure 1
Figure 1. Lassa virus (LASV) localization in guinea pigs that died of or survived infection with LASV-Josiah in study of LASV targeting of anterior uvea and endothelium of cornea and conjunctiva in eye. Primary diagram at top shows major structures of the eye; smaller diagrams detail the general regions in which LASV antigen (red circles) was detected in the eye of each animal by immunohistochemical analysis. All animals were euthanized because of disease (14–23 days postinfection) except Jos-2, which did not exhibit overt clinical signs (no weight loss or elevated body temperature) and was euthanized at study completion (41 days postinfection).
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