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Volume 25, Number 5—May 2019
Research

Lassa Virus Targeting of Anterior Uvea and Endothelium of Cornea and Conjunctiva in Eye of Guinea Pig Model

Joy M. Gary, Stephen R. Welch, Jana M. Ritter, JoAnn Coleman-McCray, Thanhthao Huynh, Markus H. Kainulainen, Brigid C. Bollweg, Vaunita Parihar, Stuart T. Nichol, Sherif R. Zaki, Christina F. Spiropoulou, and Jessica R. SpenglerComments to Author 
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA

Main Article

Figure 1

Lassa virus (LASV) localization in guinea pigs that died of or survived infection with LASV-Josiah in study of LASV targeting of anterior uvea and endothelium of cornea and conjunctiva in eye. Primary diagram at top shows major structures of the eye; smaller diagrams detail the general regions in which LASV antigen (red circles) was detected in the eye of each animal by immunohistochemical analysis. All animals were euthanized because of disease (14–23 days postinfection) except Jos-2, which did

Figure 1. Lassa virus (LASV) localization in guinea pigs that died of or survived infection with LASV-Josiah in study of LASV targeting of anterior uvea and endothelium of cornea and conjunctiva in eye. Primary diagram at top shows major structures of the eye; smaller diagrams detail the general regions in which LASV antigen (red circles) was detected in the eye of each animal by immunohistochemical analysis. All animals were euthanized because of disease (14–23 days postinfection) except Jos-2, which did not exhibit overt clinical signs (no weight loss or elevated body temperature) and was euthanized at study completion (41 days postinfection).

Main Article

Page created: April 18, 2019
Page updated: April 18, 2019
Page reviewed: April 18, 2019
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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