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Volume 25, Number 5—May 2019
Research

Lassa Virus Targeting of Anterior Uvea and Endothelium of Cornea and Conjunctiva in Eye of Guinea Pig Model

Joy M. Gary, Stephen R. Welch, Jana M. Ritter, JoAnn Coleman-McCray, Thanhthao Huynh, Markus H. Kainulainen, Brigid C. Bollweg, Vaunita Parihar, Stuart T. Nichol, Sherif R. Zaki, Christina F. Spiropoulou, and Jessica R. SpenglerComments to Author 
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA

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Figure 5

T-lymphocyte inflammation predominant in the eyes of animals that died of Lassa virus (LASV) infection >17 days postinfection in study of LASV targeting of anterior uvea and endothelium of cornea and conjunctiva in eye. CD3+ (left) and CD79a+ (right) lymphocyte antigens targeted by immunohistochemical (IHC) analysis are stained red. A) Inflamed filtration angle and sclera highlighting CD3+ T-lymphocytes. Original magnification ×10. B) Inflamed filtration angle and sclera highlighting the pred

Figure 5. T-lymphocyte inflammation predominant in the eyes of animals that died of Lassa virus (LASV) infection >17 days postinfection in study of LASV targeting of anterior uvea and endothelium of cornea and conjunctiva in eye. CD3+ (left) and CD79a+ (right) lymphocyte antigens targeted by immunohistochemical (IHC) analysis are stained red. A) Inflamed filtration angle and sclera highlighting CD3+ T-lymphocytes. Original magnification ×10. B) Inflamed filtration angle and sclera highlighting the predominant population of CD79a+ B-lymphocytes. Original magnification ×10. C) Mildly inflamed filtration angle and sclera showing the predominance of CD3+ T-lymphocytes within the region. Original magnification ×10. D) Absence of CD79a+ B-lymphocytes. Original magnification ×10. E) New vessel formation at the margin of the cornea, indicating scattered CD3+ T-lymphocytes. Original magnification ×20. F) Minimal CD79a+ B-lymphocytes. Original magnification ×20. Representative animals: A, B, Jos-1; C–F, Jos-5.

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Page created: April 18, 2019
Page updated: April 18, 2019
Page reviewed: April 18, 2019
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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