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Volume 25, Number 6—June 2019
Research

Performance of 2 Commercial Serologic Tests for Diagnosing Zika Virus Infection

Séverine Matheus, Cheikh Talla, Bhety Labeau, Franck de Laval, Sébastien Briolant, Lena Berthelot, Muriel Vray, and Dominique RoussetComments to Author 
Author affiliations: Institut Pasteur de la Guyane, Cayenne, French Guiana (S. Matheus, B. Labeau, L. Berthelot, D. Rousset); Institut Pasteur de Dakar, Dakar, Senegal (C. Talla, M. Vray); French Armed Forces Health Service in French Guiana, Cayenne (F. de Laval); French Military Centre for Epidemiology and Public Health, Marseille, France (F. de Laval); Institut de Recherche Biomédicale des Armées, Marseille (S. Briolant); Aix Marseille Université, Marseille (S. Briolant)

Main Article

Table 2

Performance of Zika virus IgM and IgG assays in panels of characterized samples obtained during days 3–20 after onset of symptoms*

Results Zika subgroup Non–Zika subgroup
 Total Sensitivity (95% CI), specificity (95% CI)
All Zika–/DENV+ Zika–/CHIKV+ Zika–/DENV–/CHIKV–
Euroimmun IgM test
Positive 41 1 0 0 1 42 49% (38–60), 99% (97–100)
Negative 43 108 35 29 44 151
Inconclusive 6 0 0 0 0 6
Total
 90
 109
 35
 29
 45
 199
Dia.Pro IgM test
Positive 59 4 3 1 0 63 69% (59–79), 96% (92–100)
Negative 27 103 30 28 45 130
Inconclusive 4 2 2 0 0 6
Total
 90
 109
 35
 29
 45
 199
Euroimmun IgG test
Positive 58 30 14 11 5 88 71% (61–81), 70% (61–79)
Negative 24 71 21 13 37 95
Inconclusive 8 8 0 5 3 16
Total
 90
 109
 35
 29
 45
 199
Dia.Pro IgG test
Positive 67 40 14 17 9 107 79% (70–88), 62% (53–71)
Negative 18 66 21 12 33 84
Inconclusive 5 3 0 0 3 8
Total 90 109 35 29 45 199

*CHIKV, chikungunya virus; DENV, dengue virus; +, positive; –, negative.

Main Article

Page created: May 20, 2019
Page updated: May 20, 2019
Page reviewed: May 20, 2019
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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