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Volume 25, Number 6—June 2019

Performance of 2 Commercial Serologic Tests for Diagnosing Zika Virus Infection

Séverine Matheus, Cheikh Talla, Bhety Labeau, Franck de Laval, Sébastien Briolant, Lena Berthelot, Muriel Vray, and Dominique RoussetComments to Author 
Author affiliations: Institut Pasteur de la Guyane, Cayenne, French Guiana (S. Matheus, B. Labeau, L. Berthelot, D. Rousset); Institut Pasteur de Dakar, Dakar, Senegal (C. Talla, M. Vray); French Armed Forces Health Service in French Guiana, Cayenne (F. de Laval); French Military Centre for Epidemiology and Public Health, Marseille, France (F. de Laval); Institut de Recherche Biomédicale des Armées, Marseille (S. Briolant); Aix Marseille Université, Marseille (S. Briolant)

Main Article

Table 3

Rate and ratio of false Zika virus IgG–positive samples obtained with Euroimmun and Dia.Pro Zika virus IgG assays according to the non–Zika virus sample subgroup

Test Positive for 
dengue virus, 
collected before 2013 Positive for chikungunya virus, collected in 2014 Negative for Zika, dengue, and chikungunya viruses, 
collected at end of 2015
Euroimmun IgG test
False positivity rate, % (pos/pos + neg) 40% (14/35) 45.8% (11/24) 11.9% (5/42)
IgG S/C ratio of false-positive IgG, mean (range)
3.9 (1.1–6.7)
2.0 (1.2–2.9)
2.0 (1.3−3.7)
Dia.Pro IgG test
False positivity rate, % (pos/pos + neg) 40% (14/35) 58.6% (17/29) 21.4% (9/42)
IgG S/C ratio of false-positive IgG, mean (range) 9.2 (2.5–14.4) 3.1 (1.1–7.7) 4.3 (1.1–10.1)

*Neg, negative; pos, positive.

Main Article

Page created: May 20, 2019
Page updated: May 20, 2019
Page reviewed: May 20, 2019
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