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Volume 25, Number 6—June 2019
Synopsis

Immunopathology of Fatal Human Variegated Squirrel Bornavirus 1 Encephalitis, Germany, 2011–2013

Dennis TappeComments to Author , Jonas Schmidt-Chanasit, Jessica Rauch, Petra Allartz, and Christiane Herden
Author affiliations: Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany (D. Tappe, J. Schmidt-Chanasit, J. Rauch, P. Allartz); German Centre for Infection Research, Hamburg (J. Schmidt-Chanasit); University of Giessen, Giessen, Germany (C. Herden)

Main Article

Figure 2

Demonstration of neutrophils, B cells, and CD4+ and CD8+ T-lymphocyte infiltration of the brain parenchyma during variegated squirrel bornavirus 1 infection. A) Demonstration of CD177+ neutrophils infiltrating the brain parenchyma from a blood vessel. Neutrophils are also seen scattered throughout the tissue during the infection. Immunoperoxidase stain with hematoxylin counterstain; original magnification ×200. B) Depiction of B cells (CD20, blue) and T cells (CD3, red) around a blood vessel. B

Figure 2. Demonstration of neutrophils, B cells, and CD4+ and CD8+ T-lymphocyte infiltration of the brain parenchyma during variegated squirrel bornavirus 1 infection. A) Demonstration of CD177+ neutrophils infiltrating the brain parenchyma from a blood vessel. Neutrophils are also seen scattered throughout the tissue during the infection. Immunoperoxidase stain with hematoxylin counterstain; original magnification ×200. B) Depiction of B cells (CD20, blue) and T cells (CD3, red) around a blood vessel. B cells showed mainly perivascular cuffing, and only a few were found in the brain parenchyma, whereas T cells were also seen in high numbers infiltrating the brain parenchyma. Immunoperoxidase and immunophosphatase stains; original magnification ×200. C, D) Mixed CD4+ (red) and CD8+ (blue) T-cell infiltrates around a blood vessel and invading adjacent tissue (C), and the hippocampus (D). Immunoperoxidase and immunophosphatase stains; original magnification ×400.

Main Article

CrossRef reports the first page should be "A793", not "d541". (Ref. 8 "Stitz, Bilzer, Planz, 2002")

CrossRef reports the first page should be "1", not "379817". (Ref. 17 "Khan, Ahmad, Alshammari, Adnan, Baig, Lohani, et al., 2015")

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Page updated: May 20, 2019
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