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Volume 25, Number 6—June 2019

Immunopathology of Fatal Human Variegated Squirrel Bornavirus 1 Encephalitis, Germany, 2011–2013

Dennis TappeComments to Author , Jonas Schmidt-Chanasit, Jessica Rauch, Petra Allartz, and Christiane Herden
Author affiliations: Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany (D. Tappe, J. Schmidt-Chanasit, J. Rauch, P. Allartz); German Centre for Infection Research, Hamburg (J. Schmidt-Chanasit); University of Giessen, Giessen, Germany (C. Herden)

Main Article

Table 2

Real-time RT-PCR results for variegated squirrel bornavirus 1 RNA in different brain areas and internal organs, Germany*

Sample Cycle threshold
Patient 1 Patient 2 Patient 3
Cortical biopsy 31.2 30.8 NA
Cortex frontal NA 31.1 29.9
Cortex temporal NA 27.9 28.9
Striatum NA 28.9 29.7
Hippocampus NA 28.3 29.4
Midbrain/substantia nigra NA 26.4 29.4
Cerebellum NA 34.6 29.9
Olfactory bulb NA NA 29.7
Myocardium NA Neg Neg
Lungs NA Neg Neg
Kidney NA Neg Neg
Liver NA Neg Neg
Spleen NA Neg Neg

*All materials tested were formalin-fixed paraffin-embedded tissue specimens. Not all tissues were available from all patients because no autopsy was performed on patient 1 and no biopsy sample was taken from patient 3. From patient 4, real-time RT-PCR analyses for variegated squirrel bornavirus 1 RNA in different brain areas and internal organs were performed earlier (2). NA, not available; neg, negative; RT-PCR, reverse transcription PCR.

Main Article

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CrossRef reports the first page should be "A793", not "d541". (Ref. 8 "Stitz, Bilzer, Planz, 2002")

CrossRef reports the first page should be "1", not "379817". (Ref. 17 "Khan, Ahmad, Alshammari, Adnan, Baig, Lohani, et al., 2015")

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Page updated: May 20, 2019
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