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Volume 25, Number 6—June 2019
Dispatch

Multirecombinant Enterovirus A71 Subgenogroup C1 Isolates Associated with Neurologic Disease, France, 2016–2017

Stéphanie Tomba Ngangas, Alexander Lukashev, Gwendoline Jugie, Olga Ivanova, Jean-Michel Mansuy, Catherine Mengelle, Jacques Izopet, Anne-Sophie L’honneur, Flore Rozenberg, David Leyssene, Denise Hecquet, Stéphanie Marque-Juillet, David Boutolleau, Sonia Burrel, Hélène Peigue-Lafeuille, Christine Archimbaud, Kimberley Benschop, Cécile Henquell, Audrey Mirand, and Jean-Luc BaillyComments to Author 
Author affiliations: Université Clermont Auvergne, Clermont-Ferrand, France (S. Tomba Ngangas, G. Jugie, H. Peigue-Lafeuille, C. Archimbaud, C. Henquell, A. Mirand, J.-L. Bailly); Sechenov University, Moscow, Russia (A. Lukashev, O. Ivanova); Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products, Moscow (O. Ivanova); Centre Hospitalier Universitaire de Toulouse, Toulouse, France (J.-M. Mansuy, C. Mengelle, J. Izopet); Assistance Publique-Hôspitaux de Paris Cochin, Paris, France (A.-S. L’honneur, F. Rozenberg); Centre Hospitalier de la Côte Basque, Bayonne, France (D. Leyssene); Centre Hospitalier Universitaire Amiens, Amiens, France (D. Hecquet); Centre Hospitalier de Versailles, Le Chesnay, France (S. Marque-Juillet); Assistance Publique-Hôspitaux de Paris Pitié-Salpêtrière-Charles Foix, Paris (D. Boutolleau, S. Burrel); CHU Clermont-Ferrand, Clermont-Ferrand (H. Peigue-Lafeuille, C. Archimbaud, C. Henquell, A. Mirand, J.-L. Bailly); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (K. Benschop)

Main Article

Table 2

Estimation of year of MRCA of EV-A71 subgenogroup C1v2015 lineage by using different enteroviruses*

Node† Year of MRCA (95% HPD interval)
Genomic region P1 3Dpol gene
1‡ 2013.6 (2013.2–2014.1) 2013.6 (2012.9–2014.3)
2§ 2010.2 (2009–2011.3) 2004.1 (2001.7–2006.2)
3¶ 2000.5 (2000.1–2001.6) ND
Root 1986 (1984.7–1987.3) ND

*EV-A71, enterovirus A71; HPD, highest probability density; MRCA, most recent common ancestor; ND, not done.
†MRCAs were determined for nodes and root in Figure 2.
‡Node 1 represents the MRCA of all included EV-A71 C1v2015 isolates except the virus from patient 14.
§For genomic region P1, node 2 represents the MRCA of all EV-A71 C1v2015 isolates, including the virus from patient 14. For 3Dpol gene, node 2 represents the MRCA of EV-A71 C1v2015 and its parent C1 lineage.
¶Node 3 represents the MRCA of EV-A71 C1v2015 and its parent C1 lineage.

Main Article

Page created: May 20, 2019
Page updated: May 20, 2019
Page reviewed: May 20, 2019
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