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Volume 25, Number 8—August 2019
Research

17DD Yellow Fever Revaccination and Heightened Long-Term Immunity in Populations of Disease-Endemic Areas, Brazil

Ana Carolina Campi-AzevedoComments to Author , Vanessa Peruhype-Magalhāes, Jordana Grazziela Coelho-dos-Reis, Lis Ribeiro Antonelli, Christiane Costa-Pereira, Elaine Speziali, Laise Rodrigues Reis, Jandira Aparecida Lemos, José Geraldo Leite Ribeiro, Luiz Antônio Bastos Camacho, Maria de Lourdes de Sousa Maia, Sheila Maria Barbosa de Lima, Marisol Simões, Reinaldo de Menezes Martins, Akira Homma, Luiz Cosme Cota Malaquias, Pedro Luiz Tauil, Pedro Fernando Costa Vasconcelos, Alessandro Pecego Martins Romano, Carla Magda Domingues, Andréa Teixeira-Carvalho, Olindo Assis Martins-FilhoComments to Author , and Collaborative Group for Studies of Yellow Fever Vaccine
Author affiliations: Instituto René Rachou of Fundação Oswaldo Cruz (FIOCRUZ-Minas),; Belo Horizonte, Brazil (A.C. Campi-Azevedo, V. Peruhype-Magalhāes, J.G. Coelho-dos-Reis, L.R. Antonelli, C. Costa-Pereira, E. Speziali, L.R. Reis, A. Teixeira-Carvalho, O.A. Martins-Filho); Universidade Federal de Minas Gerais, Belo Horizonte (J.G. Coelho-dos-Reis); Secretaria Municipal de Saúde, Belo Horizonte (J.A. Lemos); Secretaria do Estado de Saúde de Minas Gerais, Belo Horizonte (J.G.L. Ribeiro); Escola Nacional de Saúde Pública (FIOCRUZ-Rio), Rio de Janeiro, Brazil (L.A.B. Camacho); Instituto de Tecnologia em Imunobiológicos Bio-Manguinhos (FIOCRUZ-Rio),; Rio de Janeiro (M. de Lourdes de Sousa Maia, S.M. Barbosa de Lima, M. Simões, R. de Menezes Martins, A. Homma); Universidade Federal de Alfenas, Alfenas, Brazil (L.C.C. Malaquias); Universidade de Brasília, Brasília, Brazil (P.L. Tauil); Instituto Evandro Chagas, Ananindeua, Brazil (P.F.C. Vasconcelos); Secretaria de Vigilância em Saúde—Ministério da Saúde, Brasília (A.P.M. Romano, C.M. Domingues)

Main Article

Figure 3

Phenotypic memory biomarkers before and after primary and secondary 17DD vaccination for YF. Distinct T-cell memory subsets included naive T cells/(NCD4;NCD8)/CD27+CD45RO–; early effector memory T cells/(eEfCD4;eEfCD8)/CD27–CD45RO–; central memory T cells/(CMCD4;CMCD8)/CD27+CD45RO+ and effector memory T cells/(EMCD4;EMCD8)/CD27–CD45RO+. B-cell memory subsets included naive B cells/(NCD19)/CD27–IgD+; nonclassical memory B cells/(nCMCD19)/CD27+IgD+ and classical memory B cells/(CMCD19)/CD27+IgD–.W

Figure 3. Phenotypic memory biomarkers before and after primary and secondary 17DD vaccination for YF. Distinct T-cell memory subsets included naive T cells/(NCD4;NCD8)/CD27+CD45RO–; early effector memory T cells/(eEfCD4;eEfCD8)/CD27–CD45RO–; central memory T cells/(CMCD4;CMCD8)/CD27+CD45RO+ and effector memory T cells/(EMCD4;EMCD8)/CD27–CD45RO+. B-cell memory subsets included naive B cells/(NCD19)/CD27–IgD+; nonclassical memory B cells/(nCMCD19)/CD27+IgD+ and classical memory B cells/(CMCD19)/CD27+IgD–.We performed intra-arm analyses by paired t-test to compare memory-related phenotypic features observed in participants with previous vaccination with paired samples collected early after vaccination: NV(d0) versus PV(d30–45) and #PV(y≥10) versus RV(d30–45). Asterisks (*) indicate significant differences (p<0.05); vertical error bars indicate SEM. For intergroup analysis, we used adjusted analysis of variance to compare the memory-related phenotypic features observed among distinct time points; bars connecting subgroups indicate significant differences (p<0.05) between postvaccination subgroups. Participant subgroups indicate number of days or years since vaccination (in parentheses; d0 for those never vaccinated).

Main Article

Page created: July 16, 2019
Page updated: July 16, 2019
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