Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 25, Number 8—August 2019
Research

17DD Yellow Fever Revaccination and Heightened Long-Term Immunity in Populations of Disease-Endemic Areas, Brazil

Ana Carolina Campi-AzevedoComments to Author , Vanessa Peruhype-Magalhāes, Jordana Grazziela Coelho-dos-Reis, Lis Ribeiro Antonelli, Christiane Costa-Pereira, Elaine Speziali, Laise Rodrigues Reis, Jandira Aparecida Lemos, José Geraldo Leite Ribeiro, Luiz Antônio Bastos Camacho, Maria de Lourdes de Sousa Maia, Sheila Maria Barbosa de Lima, Marisol Simões, Reinaldo de Menezes Martins, Akira Homma, Luiz Cosme Cota Malaquias, Pedro Luiz Tauil, Pedro Fernando Costa Vasconcelos, Alessandro Pecego Martins Romano, Carla Magda Domingues, Andréa Teixeira-Carvalho, Olindo Assis Martins-FilhoComments to Author , and Collaborative Group for Studies of Yellow Fever Vaccine
Author affiliations: Instituto René Rachou of Fundação Oswaldo Cruz (FIOCRUZ-Minas),; Belo Horizonte, Brazil (A.C. Campi-Azevedo, V. Peruhype-Magalhāes, J.G. Coelho-dos-Reis, L.R. Antonelli, C. Costa-Pereira, E. Speziali, L.R. Reis, A. Teixeira-Carvalho, O.A. Martins-Filho); Universidade Federal de Minas Gerais, Belo Horizonte (J.G. Coelho-dos-Reis); Secretaria Municipal de Saúde, Belo Horizonte (J.A. Lemos); Secretaria do Estado de Saúde de Minas Gerais, Belo Horizonte (J.G.L. Ribeiro); Escola Nacional de Saúde Pública (FIOCRUZ-Rio), Rio de Janeiro, Brazil (L.A.B. Camacho); Instituto de Tecnologia em Imunobiológicos Bio-Manguinhos (FIOCRUZ-Rio),; Rio de Janeiro (M. de Lourdes de Sousa Maia, S.M. Barbosa de Lima, M. Simões, R. de Menezes Martins, A. Homma); Universidade Federal de Alfenas, Alfenas, Brazil (L.C.C. Malaquias); Universidade de Brasília, Brasília, Brazil (P.L. Tauil); Instituto Evandro Chagas, Ananindeua, Brazil (P.F.C. Vasconcelos); Secretaria de Vigilância em Saúde—Ministério da Saúde, Brasília (A.P.M. Romano, C.M. Domingues)

Main Article

Figure 4

Functional biomarkers specific to 17DD vaccine for YF before and after primary and secondary vaccination. We performed analysis upon in vitro 17DD-YF antigen recall of peripheral blood mononuclear cells. Flow cytometric immunophenotypic staining were performed to quantity functional T-cell subsets producing TNF-α, IFN-γ, IL-10, and IL-5 and B-cell subsets producing TNF-α, IL-10, and IL-5. We performed intra-arm analyses by paired t-test to compare memory-related functional features observed in p

Figure 4. Functional biomarkers specific to 17DD vaccine for YF before and after primary and secondary vaccination. We performed analysis upon in vitro 17DD-YF antigen recall of peripheral blood mononuclear cells. Flow cytometric immunophenotypic staining were performed to quantity functional T-cell subsets producing TNF-α, IFN-γ, IL-10, and IL-5 and B-cell subsets producing TNF-α, IL-10, and IL-5. We performed intra-arm analyses by paired t-test to compare memory-related functional features observed in previously vaccinated participants with paired samples collected early after vaccination. Asterisks (*) indicate significant differences (p<0.05); vertical error bars indicate SEM. For intergroup analysis, we used adjusted analysis of variance to compare the memory-related phenotypic features observed among distinct time points; connecting lines indicate significant differences. Participant subgroups indicate number of days or years since vaccination (in parentheses; d0 for those never vaccinated). IFN, interferon; IL, interleukin; TNF, tumor necrosis factor; YF, yellow fever.

Main Article

Page created: July 16, 2019
Page updated: July 16, 2019
Page reviewed: July 16, 2019
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external