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Volume 26, Number 12—December 2020
CME ACTIVITY - Research

Clinical and Multimodal Imaging Findings and Risk Factors for Ocular Involvement in a Presumed Waterborne Toxoplasmosis Outbreak, Brazil1

Camilo Brandão-de-Resende, Helena Hollanda Santos, Angel Alessio Rojas Lagos, Camila Munayert Lara, Jacqueline Souza Dutra Arruda, Ana Paula Maia Peixoto Marino, Lis Ribeiro do Valle Antonelli, Ricardo Tostes Gazzinelli, Ricardo Wagner de Almeida Vitor, and Daniel Vitor Vasconcelos-SantosComments to Author 
Author affiliations: Universidade Federal de Minas Gerais, Belo Horizonte, Brazil (C. Brandão-de-Resende, H.H. Santos, A.A.R. Lagos, C.M. Lara, J.S.D. Arruda, R.W.A, Vitor, D.V. Vasconcelos-Santos); Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte (A.P.M.P. Marino, L.R.V. Antonelli, R.T. Gazzinelli).

Main Article

Table 1

Characteristics and ocular signs and symptoms among patients with confirmed acute toxoplasmosis infection at baseline examination, Brazil*

Characteristics
Total, n = 52
No ocular involvement, n = 40
Ocular involvement, n = 12
p value
Age at infection, y, median (IQR)† 34 (27–40) 32 (22–38) 43 (40–47) <0.01
>40 years of age† 14 (27) 6 (15) 9 (75) <0.01
Sex
M 44 (84.6) 33 (82.5) 11 (91.7) 0.50
F
8 (15.4)
7 (17.5)
1 (8.3)
0.50
Follow-up length, mo, median (IQR)
36 (19–36)
36 (12–36)
35 (24–37)
0.32
Underlying conditions
Arterial hypertension 7 (13.5) 4 (10.0) 3 (25.0) 0.23
Diabetes mellitus
1 (1.9)
0
1 (8.3)
0.23
General signs and symptoms
Fever 49 (94.2) 38 (95.0) 11 (91.7) 0.68
Headache 33 (63.5) 25 (62.5) 8 (66.7) 0.81
Myalgia 30 (57.7) 22 (55.0) 8 (66.7) 0.50
Lymphadenopathy
8 (15.4)
7 (17.5)
1 (8.3)
0.50
Ocular signs and symptoms
VA at baseline, logMAR, median (IQR)†‡ 0.0 (0.0–0.0) 0.0 (0.0–0.0) 0.1 (0.0–0.6) 0.01
Eye pain 8 (15.4) 5 (12.5) 3 (25.0) 0.33
Self-reported recent reduction of VA† 10 (19.2) 1 (2.5) 9 (75.0) <0.01
Floaters† 3 (5.7) 0 3 (25.0) 0.01

*Values are no. (%), except as indicated. Mann-Whitney-Wilcoxon test was used to compare continuous and the mid-p exact tests for proportions between subgroups. IQR, interquartile range; logMAR, logarithm of the Minimum Angle of Resolution scale; VA, visual acuity.
†Statistical significant at α = 5%.
‡For visual acuity baseline, binocular involvement was considered the worst VA.

Main Article

1Presented in part at the 2015 American Uveitis Society Fall meeting, November 15, 2014, Las Vegas, Nevada, USA

Page created: October 05, 2020
Page updated: November 19, 2020
Page reviewed: November 19, 2020
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