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Volume 26, Number 12—December 2020

Sensitive Detection of SARS-CoV-2–Specific Antibodies in Dried Blood Spot Samples

Gabriella L. Morley, Stephen Taylor, Sian Jossi, Marisol Perez-Toledo, Sian E. Faustini, Edith Marcial-Juarez, Adrian M. Shields, Margaret Goodall, Joel D. Allen, Yasunori Watanabe, Maddy L. Newby, Max Crispin, Mark T. Drayson, Adam F. Cunningham, Alex G. Richter1, and Matthew K. O’Shea1Comments to Author 
Author affiliations: University of Birmingham, Birmingham, UK (G.L. Morley, S. Taylor, S. Jossi, M. Perez-Toledo, S.E. Faustini, E. Marcial-Juarez, A.M. Shields, M. Goodall, M.T. Drayson, A.F. Cunningham, A.G. Richter, M.K. O’Shea); The Saving Lives Charity, Birmingham (S. Taylor); University Hospitals Birmingham NHS Foundation Trust, Birmingham (S. Taylor, A.M. Shields, A.G. Richter, M.K. O’Shea); University of Southampton, Southampton, UK (J.D. Allen, Y. Watanabe, M.L. Newby, M. Crispin); University of Oxford, Oxford, UK (Y. Watanabe)

Main Article

Table 1

Mean concentrations of SARS-CoV-2 IgG, IgA, and IgM measured in matched DBS eluate and serum samples

Sample type Mean immunoglobulin concentration, g/L*
IgG (range) IgA (range) IgM (range)
DBS 1.08 (0.17–2) 0.25 (0.1–0.6) 0.13 (0.1–0.3)
Serum 11.77 (8.18–18.59) 2.55 (1.5–5.2) 0.99 (0.3–1.5)

*DBS, dried blood spot; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.
†Includes 10 matched DBS and serum and 5 pre–August 2019 DBS.

Main Article

1These senior authors contributed equally to this article.

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