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Volume 26, Number 2—February 2020

Novel Subclone of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 11 with Enhanced Virulence and Transmissibility, China

Kai Zhou1, Tingting Xiao1, Sophia David1, Qin Wang, Yanzi Zhou, Lihua Guo, David Aanensen, Kathryn E. Holt, Nicholas R. Thomson, Hajo Grundmann2, Ping Shen2, and Yonghong Xiao2Comments to Author 
Author affiliations: First Affiliated Hospital of Southern University of Science and Technology (Shenzhen People’s Hospital); Shenzhen, China (K. Zhou); The Second Clinical Medical College of Jinan University, Shenzhen (K. Zhou); Zhejiang University, Hangzhou, China (T. Xiao, Q. Wang, Y. Zhou, L. Guo, P. Shen, Y. Xiao); Centre for Genomic Pathogen Surveillance, Cambridge, UK (S. David, D. Aanensen); University of Melbourne, Melbourne, Victoria, Australia (K.E. Holt); London School of Hygiene and Tropical Medicine, London, UK (K.E. Holt, N.R. Thomson); Wellcome Trust Sanger Centre, Cambridge (N.R. Thomson); University of Freiburg, Freiburg, Germany (H. Grundmann)

Main Article

Table 1

Prevalence trend of Klebsiella pneumoniae causing BSIs in a tertiary hospital, China, 2013–2017*

Isolate type 2013 2014 2015 2016 2017 (half year) Score test for trend p value†
Primary BSI/non-BSI isolates 123/610 133/635 201/723 149/687 99/398 1.3934 0.1635
CRKP/non-CRKP 21/102 35/98 53/148 49/100 45/54 6.0697 <0.001
CRKP-ST11/non-ST11 CRKP 20/1 28/7 46/7 39/10 41/4 −0.3116 0.7553
ST11-KL47/ST11-KL64 18/1 20/4 22/23 11/28 5/36 −7.5463 <0.001

*BSI, bloodstream infection; CRKP, carbapenem-resistant Klebsiella pneumoniae; ST, sequence type.
†Calculated by using Chochran–Armitage trend test.

Main Article

1These first authors contributed equally to this article.

2These senior authors contributed equally to this article.

Page created: January 17, 2020
Page updated: January 17, 2020
Page reviewed: January 17, 2020
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