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Volume 26, Number 3—March 2020
Research

Genomic and Phenotypic Variability in Neisseria gonorrhoeae Antimicrobial Susceptibility, England

Katy TownComments to Author , Simon Harris, Leonor Sánchez-Busó, Michelle J. Cole, Rachel Pitt, Helen Fifer, Hamish Mohammed, Nigel Field, and Gwenda Hughes
Author affiliations: National Institute for Health Research, London, UK (K. Town, G. Hughes); Public Health England, London (K. Town, M.J. Cole, R. Pitt, H. Fifer, H. Mohammed, G. Hughes); University College London, London (K. Town, N. Field, G. Hughes); Microbiotica Ltd, Cambridge, UK (S. Harris); Wellcome Sanger Institute, Cambridge (S. Harris, L. Sánchez-Busó); University of Oxford, Oxford, UK (L. Sánchez-Busó)

Main Article

Table 1

Univariate and multivariable analyses comparing the epidemiologic characteristics of cases of Neisseria gonorrhoeae between 2 phylogenetic lineages, England*

Characteristics Lineage, no.
      Lineage A outcomes
     Univariate
      Multivariable
A B cOR 95% CI p value aOR 95% CI p value
Total
 838
 439
Year
2013 220 106 Ref
2014 210 123 0.82 0.60–1.13 0.234
2015 260 107 1.17 0.85–1.62 0.339
2016
 148
 103
0.69
 0.49–0.98
 0.035
Clinic location
Outside London 630 136 Ref Ref
London
 463
 109
3.73
 2.86–4.88
 <0.001
1.74
 1.27–2.67
 0.001
Sex and sexual orientation
MSM 630 136 Ref Ref
MSW 150 154 0.21 0.15–0.29 <0.001 0.33 0.23–0.47 <0.001
F
 57
 149
0.08
 0.05–0.12
 <0.001
0.14
 0.09–0.22
 <0.001
Age, y
≤24 188 196 Ref Ref
25–34 342 161 2.21 1.67–2.93 <0.001 1.14 0.83–1.59 0.413
≥35
 308
 82
3.92
 2.81–5.46
 <0.001
1.68
 1.16–2.40
 0.006
Ethnicity
White 586 238 Ref Ref
Black Caribbean 51 81 0.26 0.17–0.38 <0.001 0.49 0.32–0.76 0.001
Black African 27 20 0.55 0.30–1.00 0.046 0.84 0.43–1.64 0.607
Black Other 6 4 0.61 0.17–2.18 0.442 0.57 0.14–2.37 0.441
Asian 57 17 1.36 0.78–2.39 0.280 1.86 1.01–3.45 0.048
Other 24 8 1.22 0.54–2.75 0.634 0.99 0.41–2.44 0.999
Mixed
 62
 43
0.59
 0.39–0.89
 0.011
0.82
 0.51–1.32
 0.413
Place of birth
United Kingdom 473 309 Ref
Not United Kingdom
 305
 102
1.95
 1.49–2.56
 <0.001
Symptomatic infection
No 219 119 Ref
Yes
 526
 277
1.03
 0.79–1.35
 0.818
New STI diagnosis <1 year, excluding HIV
No or unknown 615 363 Ref
Yes
 223
 75
1.75
 1.31–2.35
 <0.001
HIV status
Negative or unknown 653 398 Ref
Positive
 185
 41
2.75
 1.91–3.96
 <0.001
Number of partners in the United Kingdom <3 months of diagnosis
0 27 20 Ref
1 175 162 0.80 0.43–1.48 0.478
≥2
 304
 167
1.35
 0.73–2.48
 0.335
Travel-associated sexual partnerships <3 months of diagnosis
No 442 325 Ref
Yes 64 24 1.96 1.20–3.21 0.006

*The multivariable model was adjusted for location, gender and sexual orientation, age, and ethnicity. Bold text indicates statistical significance (p<0.05 and 95% CI does not cross 1.0). aOR, adjusted odds ratio; cOR, crude odds ratio; MSM, men who have sex with men; MSW, men who reported sexual activity exclusively with women; Ref, referent; STI, sexually transmitted infection.

Main Article

Page created: February 20, 2020
Page updated: February 20, 2020
Page reviewed: February 20, 2020
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