Table 1

Genomic and Phenotypic Variability in Neisseria gonorrhoeae Antimicrobial Susceptibility, England

Katy Town

, Simon Harris, Leonor Sánchez-Busó, Michelle J. Cole, Rachel Pitt, Helen Fifer, Hamish Mohammed, Nigel Field, and Gwenda Hughes

Author affiliations: National Institute for Health Research, London, UK (K. Town, G. Hughes); Public Health England, London (K. Town, M.J. Cole, R. Pitt, H. Fifer, H. Mohammed, G. Hughes); University College London, London (K. Town, N. Field, G. Hughes); Microbiotica Ltd, Cambridge, UK (S. Harris); Wellcome Sanger Institute, Cambridge (S. Harris, L. Sánchez-Busó); University of Oxford, Oxford, UK (L. Sánchez-Busó)

Main Article

Univariate and multivariable analyses comparing the epidemiologic characteristics of cases of Neisseria gonorrhoeae between 2 phylogenetic lineages, England*

Characteristics	Lineage, no.		Lineage A outcomes
	Lineage, no.		Univariate			Multivariable
	A	B	cOR	95% CI	p value	aOR	95% CI	p value
Total	838	439
Year
2013	220	106	Ref
2014	210	123	0.82	0.60–1.13	0.234
2015	260	107	1.17	0.85–1.62	0.339
2016	148	103	0.69	0.49–0.98	0.035
Clinic location
Outside London	630	136	Ref			Ref
London	463	109	3.73	2.86–4.88	<0.001	1.74	1.27–2.67	0.001
Sex and sexual orientation
MSM	630	136	Ref			Ref
MSW	150	154	0.21	0.15–0.29	<0.001	0.33	0.23–0.47	<0.001
F	57	149	0.08	0.05–0.12	<0.001	0.14	0.09–0.22	<0.001
Age, y
≤24	188	196	Ref			Ref
25–34	342	161	2.21	1.67–2.93	<0.001	1.14	0.83–1.59	0.413
≥35	308	82	3.92	2.81–5.46	<0.001	1.68	1.16–2.40	0.006
Ethnicity
White	586	238	Ref			Ref
Black Caribbean	51	81	0.26	0.17–0.38	<0.001	0.49	0.32–0.76	0.001
Black African	27	20	0.55	0.30–1.00	0.046	0.84	0.43–1.64	0.607
Black Other	6	4	0.61	0.17–2.18	0.442	0.57	0.14–2.37	0.441
Asian	57	17	1.36	0.78–2.39	0.280	1.86	1.01–3.45	0.048
Other	24	8	1.22	0.54–2.75	0.634	0.99	0.41–2.44	0.999
Mixed	62	43	0.59	0.39–0.89	0.011	0.82	0.51–1.32	0.413
Place of birth
United Kingdom	473	309	Ref
Not United Kingdom	305	102	1.95	1.49–2.56	<0.001
Symptomatic infection
No	219	119	Ref
Yes	526	277	1.03	0.79–1.35	0.818
New STI diagnosis <1 year, excluding HIV
No or unknown	615	363	Ref
Yes	223	75	1.75	1.31–2.35	<0.001
HIV status
Negative or unknown	653	398	Ref
Positive	185	41	2.75	1.91–3.96	<0.001
Number of partners in the United Kingdom <3 months of diagnosis
0	27	20	Ref
1	175	162	0.80	0.43–1.48	0.478
≥2	304	167	1.35	0.73–2.48	0.335
Travel-associated sexual partnerships <3 months of diagnosis
No	442	325	Ref
Yes	64	24	1.96	1.20–3.21	0.006

*The multivariable model was adjusted for location, gender and sexual orientation, age, and ethnicity. Bold text indicates statistical significance (p<0.05 and 95% CI does not cross 1.0). aOR, adjusted odds ratio; cOR, crude odds ratio; MSM, men who have sex with men; MSW, men who reported sexual activity exclusively with women; Ref, referent; STI, sexually transmitted infection.

Main Article

Page created: February 20, 2020

Page updated: February 20, 2020

Page reviewed: February 20, 2020

The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.