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Volume 26, Number 3—March 2020
Research

Genomic and Phenotypic Variability in Neisseria gonorrhoeae Antimicrobial Susceptibility, England

Katy TownComments to Author , Simon Harris, Leonor Sánchez-Busó, Michelle J. Cole, Rachel Pitt, Helen Fifer, Hamish Mohammed, Nigel Field, and Gwenda Hughes
Author affiliations: National Institute for Health Research, London, UK (K. Town, G. Hughes); Public Health England, London (K. Town, M.J. Cole, R. Pitt, H. Fifer, H. Mohammed, G. Hughes); University College London, London (K. Town, N. Field, G. Hughes); Microbiotica Ltd, Cambridge, UK (S. Harris); Wellcome Sanger Institute, Cambridge (S. Harris, L. Sánchez-Busó); University of Oxford, Oxford, UK (L. Sánchez-Busó)

Main Article

Table 2

Association between antimicrobial susceptibility of Neisseria gonorrhoeae isolates and presence in lineage A of the phylogeny, England*

Susceptibility Lineage A, no. isolates Lineage B, no. isolates aOR 95% CI p value
Reduced
Ceftriaxone, MIC ≥0.015 mg/L
No 572 418 Referent – –
Yes 263 15 15.4 8.50–27.8 <0.001
Cefixime, MIC ≥0.03 mg/L
No 544 370 Referent – –
Yes 291 63 3.97 2.76–5.76 <0.001
Azithromycin, MIC ≥0.25 mg/L
No 328 367 Referent – –
Yes
 507
 66
 7.50
 5.37–10.5
 <0.001
Resistant
Penicillin, MIC >1 mg/L or β-lactamase positive
No 671 378 Referent – –
Yes 164 55 1.33 0.92–1.93 0.134
Ciprofloxacin, MIC >0.06 mg/L
No 400 408 Referent – –
Yes 435 25 18.2 11.4–29.2 <0.001

*Each model adjusted for location inside or outside of London, and patient age, sexual orientation, and ethnicity. Nine isolates did not have MIC data. Bold text indicates statistical significance, i.e., p<0.05 and 95% CI does not cross 1. aOR, adjusted odds ratio.

Main Article

Page created: February 20, 2020
Page updated: February 20, 2020
Page reviewed: February 20, 2020
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