Volume 26, Number 3—March 2020
Research
Genomic and Phenotypic Variability in Neisseria gonorrhoeae Antimicrobial Susceptibility, England
Katy Town
, Simon Harris, Leonor Sánchez-Busó, Michelle J. Cole, Rachel Pitt, Helen Fifer, Hamish Mohammed, Nigel Field, and Gwenda Hughes
, Simon Harris, Leonor Sánchez-Busó, Michelle J. Cole, Rachel Pitt, Helen Fifer, Hamish Mohammed, Nigel Field, and Gwenda Hughes
Table 3
Epidemiologic characteristics of patients from whom Neisseria gonorrhoeae isolates were collected in the 2 largest penA-34 clusters, England*
| Characteristics |
Total |
Cluster 1, n = 57, no. (%) |
Cluster 2, n = 26, no. (%) |
p value† |
| Year | ||||
| 2013 | 26 | 26 (45.6) | 0 | <0.001‡ |
| 2014 | 29 | 14 (24.6) | 15 (57.7) | |
| 2015 | 20 | 10 (17.5) | 10 (38.5) | |
| 2016 |
8 |
7 (12.3) |
1 (3.8) |
|
| Sex and sexual orientation | ||||
| MSM | 49 | 24 (42.1) | 25 (96.2) | <0.001‡ |
| MSW | 21 | 21 (36.8) | 0 | |
| F |
13 |
12 (21.1) |
1 (3.8) |
|
| Clinic location | ||||
| Outside London | 43 | 38 (66.7) | 5 (19.2) | <0.001‡ |
| London |
40 |
19 (33.3) |
21 (80.8) |
|
| Age, y | ||||
| ≤24 | 28 | 23 (40.4) | 5 (19.2) | 0.081 |
| 25–34 | 29 | 20 (35.1) | 9 (34.6) | |
| ≥35 |
26 |
14 (24.6) |
12 (46.2) |
|
| Ethnicity | ||||
| White | 59 | 37 (68.5) | 22 (84.6) | 0.408‡ |
| Black Caribbean | 6 | 6 (11.1) | 0 | |
| Black Other | 2 | 2 (3.7) | 0 | |
| Asian | 5 | 4 (7.4) | 1 (3.8) | |
| Other | 4 | 2 (3.7) | 2 (7.7) | |
| Mixed |
4 |
3 (5.6) |
1 (3.8) |
|
| Place of birth | ||||
| United Kingdom | 40 | 30 (52.6) | 10 (38.5) | 0.262‡ |
| Not United Kingdom | 40 | 26 (45.6) | 14 (53.9) | |
| Unknown |
3 |
1 (1.7) |
2 (7.7) |
|
| Symptomatic infection | ||||
| No | 28 | 13 (24.5) | 15 (57.7) | 0.004 |
| Yes |
51 |
40 (75.5) |
11 (42.3) |
|
| New STI diagnosed <1 year, excluding HIV | ||||
| No | 68 | 51 (89.5) | 17 (65.4) | 0.013‡ |
| Yes |
15 |
6 (10.5) |
9 (34.6) |
|
| HIV status | ||||
| Negative or unknown | 70 | 53 (93.0) | 17 (65.4) | 0.003‡ |
| Positive |
13 |
4 (7.0) |
9 (34.6) |
|
| Number of sexual partners in the United Kingdom <3 mo of N. gonorrhea diagnosis | ||||
| 0 | 6 | 6 (13.3) | 0 | 0.675‡ |
| 1 | 19 | 16 (35.6) | 3 (33.3) | |
| ≥2 |
29 |
23 (51.1) |
6 (66.7) |
|
| Travel-associated sexual partnership | ||||
| No | 43 | 34 (75.6) | 9 (100) | 0.178‡ |
| Yes | 11 | 11 (24.4) | 0 | |
*Bold text indicates statistical significance (i.e., p<0.05 and 95% CI does not cross 1). MSM, men who have sex with men; MSW, men who reported sexual activity exclusively with women.
†Calculated using χ2 test, except where noted.
‡Calculated using Fisher exact test.
Page created: February 20, 2020
Page updated: February 20, 2020
Page reviewed: February 20, 2020
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