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Volume 26, Number 3—March 2020
Research

Genomic and Phenotypic Variability in Neisseria gonorrhoeae Antimicrobial Susceptibility, England

Katy TownComments to Author , Simon Harris, Leonor Sánchez-Busó, Michelle J. Cole, Rachel Pitt, Helen Fifer, Hamish Mohammed, Nigel Field, and Gwenda Hughes
Author affiliations: National Institute for Health Research, London, UK (K. Town, G. Hughes); Public Health England, London (K. Town, M.J. Cole, R. Pitt, H. Fifer, H. Mohammed, G. Hughes); University College London, London (K. Town, N. Field, G. Hughes); Microbiotica Ltd, Cambridge, UK (S. Harris); Wellcome Sanger Institute, Cambridge (S. Harris, L. Sánchez-Busó); University of Oxford, Oxford, UK (L. Sánchez-Busó)

Main Article

Table 3

Epidemiologic characteristics of patients from whom Neisseria gonorrhoeae isolates were collected in the 2 largest penA-34 clusters, England*

Characteristics
 Total
 Cluster 1, n = 57, no. (%)
 Cluster 2, n = 26, no. (%)
 p value†
Year
2013 26 26 (45.6) 0 <0.001‡
2014 29 14 (24.6) 15 (57.7)
2015 20 10 (17.5) 10 (38.5)
2016
 8
 7 (12.3)
 1 (3.8)
Sex and sexual orientation
MSM 49 24 (42.1) 25 (96.2) <0.001‡
MSW 21 21 (36.8) 0
F
 13
 12 (21.1)
 1 (3.8)
Clinic location
Outside London 43 38 (66.7) 5 (19.2) <0.001‡
London
 40
 19 (33.3)
 21 (80.8)
Age, y
≤24 28 23 (40.4) 5 (19.2) 0.081
25–34 29 20 (35.1) 9 (34.6)
≥35
 26
 14 (24.6)
 12 (46.2)
Ethnicity
White 59 37 (68.5) 22 (84.6) 0.408‡
Black Caribbean 6 6 (11.1) 0
Black Other 2 2 (3.7) 0
Asian 5 4 (7.4) 1 (3.8)
Other 4 2 (3.7) 2 (7.7)
Mixed
 4
 3 (5.6)
 1 (3.8)
Place of birth
United Kingdom 40 30 (52.6) 10 (38.5) 0.262‡
Not United Kingdom 40 26 (45.6) 14 (53.9)
Unknown
 3
 1 (1.7)
 2 (7.7)
Symptomatic infection
No 28 13 (24.5) 15 (57.7) 0.004
Yes
 51
 40 (75.5)
 11 (42.3)
New STI diagnosed <1 year, excluding HIV
No 68 51 (89.5) 17 (65.4) 0.013‡
Yes
 15
 6 (10.5)
 9 (34.6)
HIV status
Negative or unknown 70 53 (93.0) 17 (65.4) 0.003‡
Positive
 13
 4 (7.0)
 9 (34.6)
Number of sexual partners in the United Kingdom <3 mo of N. gonorrhea diagnosis
0 6 6 (13.3) 0 0.675‡
1 19 16 (35.6) 3 (33.3)
≥2
 29
 23 (51.1)
 6 (66.7)
Travel-associated sexual partnership
No 43 34 (75.6) 9 (100) 0.178‡
Yes 11 11 (24.4) 0

*Bold text indicates statistical significance (i.e., p<0.05 and 95% CI does not cross 1). MSM, men who have sex with men; MSW, men who reported sexual activity exclusively with women.
†Calculated using χ2 test, except where noted.
‡Calculated using Fisher exact test.

Main Article

Page created: February 20, 2020
Page updated: February 20, 2020
Page reviewed: February 20, 2020
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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