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Volume 26, Number 3—March 2020
Synopsis

Mycobacterium tuberculosis Complex Lineage 3 as Causative Agent of Pulmonary Tuberculosis, Eastern Sudan1

Yassir A. ShuaibComments to Author , Eltahir A.G. Khalil, Lothar H. Wieler, Ulrich E. Schaible, Mohammed A. Bakheit, Saad E. Mohamed-Noor, Mohamed A. Abdalla, Glennah Kerubo, Sönke Andres, Doris Hillemann, Elvira Richter, Katharina Kranzer, Stefan Niemann2, and Matthias Merker2Comments to Author 
Author affiliations: Freie Universität Berlin, Berlin, Germany (Y.A. Shuaib, L.H. Wieler); Research Center Borstel, Borstel, Germany (Y.A. Shuaib, U.E. Schaible, S. Andres, D. Hillemann, S. Niemann, M. Merker); Sudan University of Science and Technology, Khartoum, Sudan (Y.A. Shuaib, S.E. Mohamed-Noor, M.A. Abdalla); University of Khartoum, Khartoum, Sudan (E.A.G. Khalil, M.A. Bakheit); Robert Koch Institute, Berlin (L.H. Wieler); Kenyatta University, Nairobi, Kenya (G. Kerubo); Labor Limbach, Heidelberg, Germany (E. Richter); London School of Hygiene and Tropical Medicine, London, UK (K. Kranzer); German Center for Infection Research, Borstel Site, Borstel (S. Niemann, M. Merker)

Main Article

Table 2

Comparison of Mycobacterium tuberculosis complex isolates sampled in eastern Sudan, 2014 and 2016*

Variable Year of sample collection, no. (%) isolates
 Total no. p value
2014 2016
Lineage 0.068
L3 51 (82.3) 71 (68.3) 122
Non-L3
 11 (17.7)
 33 (31.7)
 44
DST 0.019
Any drug resistance 20 (32.3) 16 (15.4) 36
No drug resistance
 42 (67.7)
 88 (84.6)
 120
<12 SNP cluster 0.016
Clustered 36 (58.1) 40 (38.5) 76
Not clustered
 26 (41.9)
 64 (61.5)
 90
All patients 62 (100) 104 (100) 166

*DST, drug susceptibility testing; L, lineage; SNP, single-nucleotide polymorphism.

Main Article

1Preliminary results from this study were presented at the 39th Annual Congress of the European Society of Mycobacteriology, July 1–4, 2018, Dresden, Germany.

2These authors contributed equally to this article.

Page created: February 20, 2020
Page updated: February 20, 2020
Page reviewed: February 20, 2020
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