Volume 26, Number 3—March 2020
Synopsis
Mycobacterium tuberculosis Complex Lineage 3 as Causative Agent of Pulmonary Tuberculosis, Eastern Sudan1
Table 4
Performance of genotypic drug resistance prediction to first-line tuberculosis drugs in Mycobacterium tuberculosis complex strains, eastern Sudan*
Drug | Resistant |
Susceptible |
Se, %† (95% CI) | Sp, %‡ (95% CI) | PPV, %§ (95% CI) | NPV, %¶ (95% CI) | Unknown mutations (%) | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
gR (TP) | gS (FN) | gU (FN) | gR (FP) | gS (TN) | gU (TN) | |||||||
SM | 24 | 0 | 9 | 0 | 133 | 0 | 72.7 (54.5–86.7) | 100 | 100 | 93.7 (89.4–96.3) | 9/166 (5.4) | |
INH | 17 | 0 | 0 | 0 | 149 | 0 | 100 | 100 | 100 | 100 | 0/166 (0.0) | |
RIF | 17 | 0 | 0 | 0 | 149 | 0 | 100 | 100 | 100 | 100 | 0/166 (0.0) | |
EMB | 1 | 0 | 0 | 10* | 155 | 0 | 100 | 93.9 (89.1–97.1) | 9.10 (5.2–15.4) | 100 | 0/166 (0.0) | |
PZA | 1 | 0 | 0 | 0 | 165 | 0 | 100 | 100 | 100 | 100 | 0/166 (0.0) |
*See MICs in the Methods section. EMB, ethambutol; FN, false negative; FP, false positive; gR, genetically resistant; gS, genetically susceptible; gU, genetic resistance unknown; INH, isoniazid; NPV, negative predictive value; PPV, positive predictive value; PZA, pyrazinamide; RIF, rifampin; Se, sensitivity; Sp, specificity; SM, streptomycin; TN, true negative; TP, true positive.
†Se = TP ÷ TP + FN.
‡Sp = TN ÷ TN + FP.
§PPV = TP ÷ (TP + FP).
¶NPV = TN ÷ (TN + FN).
1Preliminary results from this study were presented at the 39th Annual Congress of the European Society of Mycobacteriology, July 1–4, 2018, Dresden, Germany.
2These authors contributed equally to this article.