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Volume 26, Number 8—August 2020
Research

Population Genomic Structure and Recent Evolution of Plasmodium knowlesi, Peninsular Malaysia

Suzanne E. Hocking, Paul C.S. Divis, Khamisah A. Kadir, Balbir Singh, and David J. ConwayComments to Author 
Author affiliations: London School of Hygiene and Tropical Medicine Department of Infection Biology, London, UK (S.E. Hocking, D.J. Conway); Universiti Sarawak Malaysia Malaria Research Centre, Kota Samarahan, Malaysia (P.C.S. Divis, K.A. Kadir, B. Singh, D.J. Conway)

Main Article

Figure 3

Low levels of diversity within individual Plasmodium knowlesi clinical infections from Malaysia as indicated by the high values of the genomewide within-isolate fixation index (potential range 0–1). A value of >0.95 is generally taken to indicate an infection dominated by a single genotype, whereas values <0.95 indicate infections that are clearly genotypically mixed. Each point shows the value for an individual infection sample; only 4 of the 28 cluster 3 clinical isolates from Peninsular

Figure 3. Low levels of diversity within individual Plasmodium knowlesi clinical infections from Malaysia as indicated by the high values of the genomewide within-isolate fixation index FWS (potential range 0–1). A value of >0.95 is generally taken to indicate an infection dominated by a single genotype, whereas values <0.95 indicate infections that are clearly genotypically mixed. Each point shows the value for an individual infection sample; only 4 of the 28 cluster 3 clinical isolates from Peninsular Malaysia are clearly mixed (similar to the proportions observed in infections with the cluster 1 and 2 types in Malaysian Borneo).

Main Article

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Page updated: June 25, 2020
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