IgG Seroconversion and Pathophysiology in Severe Acute Respiratory Syndrome Coronavirus 2 Infection
Henry M. Staines
1, Daniela E. Kirwan
1, David J. Clark
1, Emily R. Adams, Yolanda Augustin, Rachel L. Byrne, Michael Cocozza, Ana I. Cubas-Atienzar, Luis E. Cuevas, Martina Cusinato, Benedict M.O. Davies, Mark Davis, Paul Davis, Annelyse Duvoix, Nicholas M. Eckersley, Daniel Forton, Alice J. Fraser, Gala Garrod, Linda Hadcocks, Qinxue Hu, Michael Johnson, Grant A. Kay, Kesja Klekotko, Zawditu Lewis, Derek C. Macallan, Josephine Mensah-Kane, Stefanie Menzies, Irene Monahan, Catherine M. Moore, Gerhard Nebe-von-Caron, Sophie I. Owen, Chris Sainter, Amadou A. Sall, James Schouten, Christopher T. Williams, John Wilkins, Kevin Woolston, Joseph R.A. Fitchett, Sanjeev Krishna
2![Comments to Author](/eid/content/images/icon/email.gif)
, and Tim Planche
2
Author affiliations: St. George’s, University of London, London, UK (H.M. Staines, D.E. Kirwan, D.J. Clark, Y. Augustin, M. Cuisinato, B.M.O. Davies, N.M. Eckersley, D. Forton, L. Hadcocks, Q. Hu, D.C. Macallan, I. Monahan, C.M. Moore, S. Krishna, T. Planche); Liverpool School of Tropical Medicine, Liverpool, UK (E.R. Adams, R.L. Byrne, A.I. Cubas-Atienzar, L.E. Cuevas, A.J. Fraser, G. Garrod, G.A. Kay, S. Menzies, S.I. Owen, C.T. Williams); Mologic, Thurleigh, UK (M. Cocozza, M. Davis, P. Davis, A. Duvoix, M. Johnson, K. Klekotko, Z. Lewis, J. Mensah-Kane, G. Nebe-von-Caron, C. Sainter, J. Schouten, J. Wilkins, K. Woolston, J.R.A. Fitchett); St. George’s University Hospitals National Health Services Foundation Trust, London (D. Forton, S. Krishna, T. Planche); Institut Pasteur, Dakar, Senegal (A.A. Sall); Universitätsklinikum Tübingen, Tübingen, Germany (S. Krishna); Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon (S. Krishna)
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Figure 2
![Relationships between CRP levels, symptoms, outcomes, and NODs of patients with severe acute respiratory syndrome coronavirus 2, United Kingdom, 2020. A–C) CRPs at diagnosis for A) 113 symptomatic (open circles) and 21 asymptomatic (closed circles) patients (CRP 97 vs. 56; p<0.01); B) 62 patients admitted to intensive care and/or who died (open circles) and 72 who were not admitted to intensive care (closed circles) (CRP 107 vs. 75.5; p = 0.01); C) 123 patients who seroconverted (open circles) and 11 who did not (closed circles) (CRP 93 vs. 28; p = 0.04). D–F) Peak CRPs corresponding to the populations in A–C: D) 255 (n = 142) vs. 104 (n = 34) (p<0.01); E) 322 (n = 80) vs. 137.5 (n = 96) (p<0.01); F) 224 (n = 161) vs. 101 (n = 15) (p = 0.03). Statistical significance calculated using Mann-Whitney test for CRPs (mg/L). CRP, C-reactive protein; NOD, normalized optical density.](/eid/images/20-3074-F2.jpg)
Figure 2. Relationships between CRP levels, symptoms, outcomes, and NODs of patients with severe acute respiratory syndrome coronavirus 2, United Kingdom, 2020. A–C) CRPs at diagnosis for A) 113 symptomatic (open circles) and 21 asymptomatic (closed circles) patients (CRP 97 vs. 56; p<0.01); B) 62 patients admitted to intensive care and/or who died (open circles) and 72 who were not admitted to intensive care (closed circles) (CRP 107 vs. 75.5; p = 0.01); C) 123 patients who seroconverted (open circles) and 11 who did not (closed circles) (CRP 93 vs. 28; p = 0.04). D–F) Peak CRPs corresponding to the populations in A–C: D) 255 (n = 142) vs. 104 (n = 34) (p<0.01); E) 322 (n = 80) vs. 137.5 (n = 96) (p<0.01); F) 224 (n = 161) vs. 101 (n = 15) (p = 0.03). Statistical significance calculated using Mann-Whitney test for CRPs (mg/L). CRP, C-reactive protein; NOD, normalized optical density.
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