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Volume 27, Number 1—January 2021
Research

IgG Seroconversion and Pathophysiology in Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Henry M. Staines1, Daniela E. Kirwan1, David J. Clark1, Emily R. Adams, Yolanda Augustin, Rachel L. Byrne, Michael Cocozza, Ana I. Cubas-Atienzar, Luis E. Cuevas, Martina Cusinato, Benedict M.O. Davies, Mark Davis, Paul Davis, Annelyse Duvoix, Nicholas M. Eckersley, Daniel Forton, Alice J. Fraser, Gala Garrod, Linda Hadcocks, Qinxue Hu, Michael Johnson, Grant A. Kay, Kesja Klekotko, Zawditu Lewis, Derek C. Macallan, Josephine Mensah-Kane, Stefanie Menzies, Irene Monahan, Catherine M. Moore, Gerhard Nebe-von-Caron, Sophie I. Owen, Chris Sainter, Amadou A. Sall, James Schouten, Christopher T. Williams, John Wilkins, Kevin Woolston, Joseph R.A. Fitchett, Sanjeev Krishna2Comments to Author , and Tim Planche2Comments to Author 
Author affiliations: St. George’s, University of London, London, UK (H.M. Staines, D.E. Kirwan, D.J. Clark, Y. Augustin, M. Cuisinato, B.M.O. Davies, N.M. Eckersley, D. Forton, L. Hadcocks, Q. Hu, D.C. Macallan, I. Monahan, C.M. Moore, S. Krishna, T. Planche); Liverpool School of Tropical Medicine, Liverpool, UK (E.R. Adams, R.L. Byrne, A.I. Cubas-Atienzar, L.E. Cuevas, A.J. Fraser, G. Garrod, G.A. Kay, S. Menzies, S.I. Owen, C.T. Williams); Mologic, Thurleigh, UK (M. Cocozza, M. Davis, P. Davis, A. Duvoix, M. Johnson, K. Klekotko, Z. Lewis, J. Mensah-Kane, G. Nebe-von-Caron, C. Sainter, J. Schouten, J. Wilkins, K. Woolston, J.R.A. Fitchett); St. George’s University Hospitals National Health Services Foundation Trust, London (D. Forton, S. Krishna, T. Planche); Institut Pasteur, Dakar, Senegal (A.A. Sall); Universitätsklinikum Tübingen, Tübingen, Germany (S. Krishna); Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon (S. Krishna)

Main Article

Table 1

Demographic and clinical characteristics of patients with severe acute respiratory syndrome coronavirus 2 infection, United Kingdom, 2020*

Characteristics Results
Median age, y (IQR) 64 (52–77)
Median body mass index (IQR)†
 25.4 (21.9–30.5)
Sex
M 100 (56.5)
F
 77 (43.5)
Race
White 60 (33.9)
Non-White 61 (34.5)
Other/not known
 56 (31.6)
Concurrent conditions
0 47 (26.6)
1 52 (29.4)
2 50 (28.2)
>3
 28 (15.8)
Symptoms
Symptomatic 143 (80.8)
Median days from symptom onset to 
PCR (IQR)
 6 (3–9)
Diagnostic site
Emergency department 90 (50.8)
Outpatient 12 (6.8)
Ward 54 (30.5)
Intensive care unit 14 (7.9)
Occupational health staff
 7 (4.0)
Treatment location
Occupational health staff 7 (4.0)
Outpatient 4 (2.3)
Hospital
 166 (93.8)
Admitted to intensive care unit
 63 (38.0)
Outcomes
Never hospitalized 11 (6.2)
Discharged 108 (61.0)
Median length of stay, d (IQR) 19.3 (10.6–31.1)
Death 44 (24.9)
Median length of stay, d (IQR) 19.1 (14.8–24.8)
Death and/or ICU admission 80 (45.2)
Still in hospital‡ 14 (7.9)

*Values are no. (%) except as indicated. ICU, intensive care unit; IQR, interquartile range.
†Height unavailable for 13 patients.
‡As of May 22, 2020.

Main Article

1These first authors contributed equally to this article.

2These senior authors contributed equally to this article.

Page created: October 17, 2020
Page updated: December 21, 2020
Page reviewed: December 21, 2020
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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