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Volume 27, Number 1—January 2021
Research

IgG Seroconversion and Pathophysiology in Severe Acute Respiratory Syndrome Coronavirus 2 Infection

Henry M. Staines1, Daniela E. Kirwan1, David J. Clark1, Emily R. Adams, Yolanda Augustin, Rachel L. Byrne, Michael Cocozza, Ana I. Cubas-Atienzar, Luis E. Cuevas, Martina Cusinato, Benedict M.O. Davies, Mark Davis, Paul Davis, Annelyse Duvoix, Nicholas M. Eckersley, Daniel Forton, Alice J. Fraser, Gala Garrod, Linda Hadcocks, Qinxue Hu, Michael Johnson, Grant A. Kay, Kesja Klekotko, Zawditu Lewis, Derek C. Macallan, Josephine Mensah-Kane, Stefanie Menzies, Irene Monahan, Catherine M. Moore, Gerhard Nebe-von-Caron, Sophie I. Owen, Chris Sainter, Amadou A. Sall, James Schouten, Christopher T. Williams, John Wilkins, Kevin Woolston, Joseph R.A. Fitchett, Sanjeev Krishna2Comments to Author , and Tim Planche2Comments to Author 
Author affiliations: St. George’s, University of London, London, UK (H.M. Staines, D.E. Kirwan, D.J. Clark, Y. Augustin, M. Cuisinato, B.M.O. Davies, N.M. Eckersley, D. Forton, L. Hadcocks, Q. Hu, D.C. Macallan, I. Monahan, C.M. Moore, S. Krishna, T. Planche); Liverpool School of Tropical Medicine, Liverpool, UK (E.R. Adams, R.L. Byrne, A.I. Cubas-Atienzar, L.E. Cuevas, A.J. Fraser, G. Garrod, G.A. Kay, S. Menzies, S.I. Owen, C.T. Williams); Mologic, Thurleigh, UK (M. Cocozza, M. Davis, P. Davis, A. Duvoix, M. Johnson, K. Klekotko, Z. Lewis, J. Mensah-Kane, G. Nebe-von-Caron, C. Sainter, J. Schouten, J. Wilkins, K. Woolston, J.R.A. Fitchett); St. George’s University Hospitals National Health Services Foundation Trust, London (D. Forton, S. Krishna, T. Planche); Institut Pasteur, Dakar, Senegal (A.A. Sall); Universitätsklinikum Tübingen, Tübingen, Germany (S. Krishna); Centre de Recherches Médicales de Lambaréné, Lambaréné, Gabon (S. Krishna)

Main Article

Figure 1

Antibody dynamics in patients with severe acute respiratory syndrome coronavirus 2, United Kingdom, 2020. A) NOD by days after first positive PCR result. Blue indicates seroconverting patients; red indicates nonseroconverting patients. B) Mean (± SEM) NODs (>3 samples per time point; n = 48) by days after first positive PCR result for those who seroconverted. A 4-parameter sigmoidal unconstrained model is shown (r2 = 0.45). C) Mean (± SEM) NODs (>3 per time point; n = 45) by days after symptom onset for patients who seroconverted. A 4-parameter sigmoidal unconstrained model is shown (r2 = 0.63). NOD, normalized optical density.

Figure 1. Antibody dynamics in patients with severe acute respiratory syndrome coronavirus 2, United Kingdom, 2020. A) NOD by days after first positive PCR result. Blue indicates seroconverting patients; red indicates nonseroconverting patients. B) Mean (± SEM) NODs (>3 samples per time point; n = 48) by days after first positive PCR result for those who seroconverted. A 4-parameter sigmoidal unconstrained model is shown (r2 = 0.45). C) Mean (± SEM) NODs (>3 per time point; n = 45) by days after symptom onset for patients who seroconverted. A 4-parameter sigmoidal unconstrained model is shown (r2 = 0.63). NOD, normalized optical density.

Main Article

1These first authors contributed equally to this article.

2These senior authors contributed equally to this article.

Page created: October 17, 2020
Page updated: December 21, 2020
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